摘要
为了促进健康老龄化进程,预防与衰老相关的健康问题,正确理解衰老机制以及开发有效的抗衰老干预措施。系统注射D-半乳糖(D-galactose)已被用于人工诱导体外和体内衰老,以及抗衰老治疗干预研究。本文从氧化应激、线粒体功能障碍、免疫衰老以及对各器官的影响四个方面综述了D-半乳糖诱导衰老的特征性变化,从多角度为抗衰老提供理论依据。
We discuss studies aimed to promote a healthy aging process,prevent health problems related to aging,correctly understand the aging mechanism,and develop effective anti-aging treatment measures.Systemic injection of D-galactose has been used for artificial induction of aging in vitro and in vivo,and anti-aging research.This review summarizes the characteristic changes of aging induced by D-galactose from four aspects:oxidative stress,mitochondrial dysfunction,immune aging,and the influence of immune aging on various organs.Furthermore,a theoretical basis for anti-aging is provided from various viewpoints.
作者
洪晶
张娅俐
闫莎莎
李雪
田晓静
曹竑
张福梅
丁功涛
HONG Jing;ZHANG Yali;YAN Shasha;LI Xue;TIAN Xiaojing;CAO Hong;ZHANG Fumei;DING Gongtao(Gollege of Life Science and Engineering,Northwest Minzu University,Lanzhou 730124,China;China-Malaysia National Joint Laboratory,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030;Medical Department,Northwest Minzu University,Lanzhou 730124)
出处
《中国比较医学杂志》
CAS
北大核心
2023年第3期136-142,共7页
Chinese Journal of Comparative Medicine
基金
西北民族大学中央高校基本科研业务费资金资助项目(31920210006)
教育部动物医学生物工程创新团队(IRT_17R88)
牦牛乳全成分分析(XBMU-2020-BC-30)。
