摘要
目的探讨纳米碳标记对肥胖胃癌患者根治术后淋巴结获取数目的影响。方法回顾性分析2015年1月至2019年12月期间在郑州大学附属肿瘤医院接受胃癌D2根治术127例肥胖患者的临床资料,依据患者术中是否注射纳米碳分为2组:64例患者术中未注射纳米碳者设为对照组,63例患者术中注射纳米碳者设为研究组,分析两组的术中情况及术后淋巴结获取情况。结果对照组手术时间(160±31)min,研究组手术时间(168±28)min,差异无统计学意义(t=-1.521 P=0.445);对照组术中出血量为(234±82)ml,研究组术中出血量(238±84)ml,差异无统计学意义(t=-0.295,P=0.846)。淋巴结检出情况:对照组在第一站淋巴结检出数目、第二站淋巴结检出数目、总淋巴结检出数目、直径<5 mm淋巴结数目方面均少于研究组[(10.4±3.8)枚比(24.5±10.6)枚,t=-10.054;(6.6±2.8)枚比(16.8±7.3)枚,t=-10.381;(17.1±6.4)枚比(41.2±17.6)枚,t=-10.293;(3.9±2.5)枚比(21.2±9.1)枚,t=-14.662],差异均有统计学意义(均P<0.05)。研究组在阳性淋巴结检出数目方面多于对照组[(5.9±6.2)枚比(4.2±3.4)枚,t=-1.963],但两组差异无统计学意义(P>0.05)。研究组共检出黑染淋巴结1542枚,淋巴结黑染率59.44%(1542/2594)。结论术中纳米碳的应用可显著提高肥胖(BMI≥25 kg/m^(2))胃癌患者根治术后淋巴结的获取数目,其临床意义有待进一步明确。
Object To investigate the impact of carbon nanoparticle tracing on the number of lymph nodes harvested in obese patients during radical gastrectomy for gastric cancer.Methods Clinical data of 127 patients undergoing D2 radical gastrectomy in the Affiliated Tumor Hospital of Zhengzhou University from Jan 2015 to Dec 2019 were retrospectively analyzed.According to whether the patients were injected with carbon nano particles during operation,they were divided into two groups:64 patients without carbon nano particles during operation served as control group;63 patients with carbon nano particles were included into experimental group.Results The operation time of the control group was(160±31)min and that of the experimental group was(168±28)min(t=-1.521,P=0.445).Intraoperative blood lose in the control group was(234±82)ml and that in the experimental group was(238±84)ml(t=-0.295,P=0.846).The number of lymph nodes harvested in the first station,in the second station,the number of total lymph nodes and the number of lymph nodes with diameter<5 mm in the control group were less than those in the experimental group(10.4±3.8 vs.24.5±10.6,t=-10.054),(6.6±2.8 vs.16.8±7.3,t=-10.381),(17.1±6.4 vs.41.2±17.6,t=-10.293),(3.9±2.5 vs.21.2±9.1,t=-14.662)(all P<0.05),while the number of positive lymph nodes was not statistically different between the two groups all(5.9±6.2 vs.4.2±3.4,t=-1.963,P>0.05).Black staining of lymph nodes in nano carbon group:1542 black stained lymph nodes were detected in the experimental group,the black staining rate of lymph nodes was 59.44%(1542/2594).Conclusion Intraoperative application of carbon nanoparticles can significantly increase the number of harvested lymph nodes in obese(BMI≥25 kg/m2)gastric cancer patients after radical resection.
作者
张俊立
邵国益
黄洋洋
李森
曹养辉
刘晨宇
马鹏飞
李长征
张习杰
李振豫
赵玉洲
Junli Zhang;Guoyi Shao;Yangyang Huang;Sen Li;Yanghui Cao;Chenyu Liu;Pengfei Ma;Changzheng Li;Xijie Zhang;Zhenyu Li;Yuzhou Zhao(Department of General Surgery,Affiliated Tumor Hospital of Zhenzhou University(He'nan Tumor Hospital),Zhenzhou 450000,China)
出处
《中华普通外科杂志》
CSCD
北大核心
2022年第12期907-910,共4页
Chinese Journal of General Surgery
关键词
胃肿瘤
淋巴结
纳米碳
肥胖
胃切除术
Stomach neoplasms
Lymph nodes
Nanometer,carbon
Obesity
Gastrectomy
