摘要
目的:了解国内外单克隆抗体药物的研究热点,分析可能的研究趋势。方法:以中国知网和PubMed上公开发表的单克隆抗体药物研究文献为基础数据(检索时间为1982年1月至2022年1月),运用CiteSpace工具,对2个文献数据库进行分析,得出国内外研究的热点和不同之处。结果:通过对2个数据库文献的知识图谱分析,可以看到乳腺癌、抗体偶联药物、临床试验、靶向治疗等均是国内外文献研究的热点。结论:CiteSpace的文献研究提示,单克隆抗体药物的研究正处在大幅提升期,在肿瘤、自身免疫、代谢等疾病领域显示出独特的优势和前景;我国单克隆抗体药物研究相关的发文量居世界第4位,在此研究方面占有重要的地位。
OBJECTIVE:To investigate the research hotspots of monoclonal antibody drugs at home and abroad,and to analyze possible research trends.METHODS:Using the publicly available literature of monoclonal antibody drug research on CNKI and PubMed as basic data(retrieval time:Jan.1982 to Jan.2022),the two document databases were analyzed by using the CiteSpace tool,so as to derive the hotspots and differences of domestic and foreign research.RESULTS:The knowledge map analysis of literature in the two databases showed that breast cancer,antibody-conjugates drugs,clinical trials and targeted therapy are the hotspots of domestic and foreign literature research.CONCLUSIONS:The literature study of CiteSpace suggests that the research of monoclonal antibody drugs is in a period of substantial enhancement,which shows unique advantages and prospects in the fields of oncology,autoimmunity,metabolism and other diseases;China ranks 4th in the world in terms of the number of publications related to monoclonal antibody drug research,and occupies an important position in this research.
作者
陈宁
唐婧
李锦
杨学文
甄健存
CHEN Ning;TANG Jing;LI Jin;YANG Xuewen;ZHEN Jiancun(Dept.of Pharmacy,Beijing Jishuitan Hospital,Beijing 100035,China;Dept.of Pharmacy,Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua University/School of Clinical Medicine of Tsinghua University,Beijing 102218,China)
出处
《中国医院用药评价与分析》
2023年第1期116-119,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
