摘要
饲料在实验动物的生理发育中起着重要作用。高质量的动物饲料,可以优化大多数物种的生长、维持和繁殖。然而饲料具有高度可变性,饲料质量和组成的差异可能会影响动物/群体健康,并可能在以动物为基础的研究中引入复杂的变量,从而影响研究的再现性和可重复性。本文归纳总结了实验动物饲料差异的来源,探讨了饲料作为动物实验的外部因素如何影响动物健康、研究设计和实验结果可重复性等关键问题,并在此基础上为如何减轻这些影响提供参考。
Feed plays a central role in the physiological development of laboratory animals. High-quality animal feed can optimize growth, maintenance, and reproduction in most species. However, feeds are highly variable, and differences in feed quality and composition may affect animal/population health, and may introduce complex variables in animal-based studies, thereby affecting the reproducibility and reproducibility of studies. This article summarizes the sources of experimental animal feed differences, discusses how feed as an external factor in animal experiments affects animal health, research design, and reproducibility of experimental result, and on this basis, provides reference for how to mitigate these effects.
作者
李志萍
赵德明
周向梅
杨利峰
乔健
LI Zhiping;ZHAO Deming;ZHOU Xiangmei;YANG Lifeng;QIAO Jian(National TES Laboratory,China Agricultural University,Beijing 100193,China;College of Veterinary Medicine,China Agricultural University,Beijing 100193,China)
出处
《实验动物科学》
2022年第5期84-88,共5页
Laboratory Animal Science
基金
十三五国家重点研发计划(2017YFD0501600)。
关键词
实验动物
饲料
差异
动物研究
可重复性
laboratory animals
feed
difference
animal research
replicability
