摘要
肿瘤是多因素参与和多阶段发病的疾病,其中生物致癌因素主要有致癌性病毒、细菌及寄生虫,常见的包括乙型肝炎病毒(HBV)与肝细胞癌、EB病毒(EBV)与鼻咽癌、人乳头瘤病毒(HPV)与宫颈癌、幽门螺杆菌(Hp)与MALT淋巴瘤及胃癌等。肿瘤的发生发展与微生物密不可分,微生物可通过以下几种机制施展致癌促癌作用:产生毒性物质、诱导毒性效应、诱导炎性反应发生、影响免疫应答等。本文将微生物的致癌促癌机制相关进展做简要总结,并展望以微生物作为早期肿瘤筛查的生物标志物和以微生物作为靶点研发药物的新思路。
Tumor is a disease with multi-factor participation and multi-stage onset,among which the biological carcinogenic factors are mainly carcinogenic viruses,bacteria and parasites,and the common ones include hepatitis B virus(HPV)and hepatocellular carcinoma,Epstein-Barr virus(EBV)and nasopharyngeal carcinoma,human papilloma virus(HPV)and cervical cancer,Helicobacter pylori and MALT lymphoma,gastric cancer etc.The occurrence and development of certain tumors are closely related to microorganisms,which can play a role in carcinogenesis and cancer promotion through the following mechanisms:producing toxic substances,inducing toxic effects,inducing inflammation,affecting immune response,etc.This review briefly summarizes the carcinogenic and cancer-promoting mechanisms of microorganisms,and looks forward to the new ideas of using microorganisms as biomarkers for early tumor screening and developing drugs by targeting microorganisms.
作者
孙慧
陈思宇
SUN Hui;CHEN Siyu(Department of Oncology,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)
出处
《基础医学与临床》
2023年第1期178-182,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(82074074,81874353)。
关键词
微生物
肿瘤
发病机制
早期筛查
治疗
microorganism
tumor
pathogenesis
early screening
treatment
