摘要
纳米碳酸钙是指粒径在1~100 nm之间的碳酸钙颗粒,它因具有某些特殊性质,如量子尺寸效应、表面效应等而被广泛用于橡胶工业、食品加工业、化妆品及医药领域。随着纳米碳酸钙的生产和使用,它们大量进入生态系统,并通过呼吸道、消化道和皮肤等途径进入人体,从而引起人们对其潜在健康风险的关注。目前很多研究报道,纳米碳酸钙在细胞水平及动物体内均具有一定的毒性作用,但大多只是针对单一的暴露途径进行分析,毒性机制也各不相同,并没有明确定论。因此,基于碳酸钙这类本身无毒或低毒性纳米颗粒的研究,本综述详细阐述纳米碳酸钙通过不同途径进入体内的转运代谢过程、体内外毒性作用和可能的毒性机制,为评估纳米碳酸钙的生物安全性提供新思路。
Nano-calcium carbonate refers to the calcium carbonate particles with size between 1~100 nm.Due to its special properties such as quantum size effect and surface effect,nano-calcium carbonate widely adopted in rubber industry,food processing,cosmetics and medicine synthesis.With the extensive production and application,a large amount of nano-calcium carbonate comes into the ecosystem,and further enters the human body through respiratory tract,digestive tract and skin,thus arousing people’s attention to their potential health risks.At present,many studies have reported that nano-calcium carbonate shows a certain toxic effect at the cellular level as well as in animals.However,most of them only analyzed a single exposure route and provided different toxicity mechanisms without clear determinism.Therefore,based on the research of calcium carbonate,non-toxic or low-toxic nano-particles,this review introduces the transport and metabolism process,in vitro and in vivo toxicity and possible toxicity mechanism through different pathways in detail.The current research is expected to provide a new idea for evaluating the biological safety of nano-calcium carbonate.
作者
严小雨
黎林均
樊苗苗
朱红瑞
吴道澄
张志强
卢金锁
Yan Xiaoyu;Li Linjun;Fan Miaomiao;Zhu Hongrui;Wu Daocheng;Zhang Zhiqiang;Lu Jinsuo(School of Environmental and Municipal Engineering,Xi’an University of Architecture and Technology,Xi’an 710055,China;Institutes of Biomedical and Health Engineering,Xi’an Jiaotong University,Xi’an 710048,China)
出处
《生态毒理学报》
CAS
CSCD
北大核心
2022年第5期260-271,共12页
Asian Journal of Ecotoxicology
基金
国家自然科学基金资助项目(51978558)
陕西省重点研发计划项目(2020NY-107)
国家重点研发计划项目(2019YFD1100102-04)。
关键词
纳米碳酸钙
暴露途径
体内转运代谢
纳米毒性
健康风险
毒性机制
nano-calcium carbonate
exposure pathways
transport metabolism in vivo
nanotoxicity
health risks
toxic mechanism
