摘要
目的系统评价自动乳腺全容积成像系统(ABVS)与手持超声(HHUS)对乳腺良、恶性病灶的诊断价值。方法检索Cochrane图书馆、PubMed、Embase、Ovid、中国知网(CNKI)、维普网(VIP)、万方医学网、中国生物医学文献数据库(CBM)等,检索时间从建库至2022年1月。筛选并纳入相关文献,提取文献特征。应用Meta-disc 1.4软件分析ABVS、HHUS诊断乳腺肿瘤的合并诊断比值比(DOR)、合并特异度、合并灵敏度及95%CI、集成受试者工作特征(SROC)曲线及曲线下面积(AUC)等,评价研究间的异质性及发表偏倚情况。结果共纳入26篇文献。异质性检验结果提示无阈值效应,采用随机效应模型合并灵敏度、特异度、DOR等效应量。ABVS和HHUS的合并灵敏度分别为0.86(95%CI 0.84~0.87)、0.80(95%CI 0.78~0.82),I2分别为89.7%和82.3%;合并特异度分别为0.91(95%CI 0.90~0.92)、0.84(95%CI 0.83~0.86),I2分别为89.7%和92.2%。ABVS、HHUS、二者联合诊断的AUC分别为0.954、0.883、0.958。漏斗图分析显示不存在发表偏倚。结论在乳腺病灶良、恶性的鉴别诊断方面,ABVS较HHUS具有更高的临床价值。
Objective To systematically assess the diagnostic value of automated breast volume scanning(ABVS)versus hand-held ultrasound(HHUS)in benign and malignant breast lesions.Methods The Cochrane Library,PubMed,Embase,Ovid,China National Knowledge Infrastructure(CNKI),VIP,Wanfang,China Biology Medicine(CBM)and other databases were searched from the beginning of database construction to January 2022.Relevant literatures were screened and included,and the characteristics of the literatures were extracted.Meta-disc 1.4 statistic software was used to analyze the pooled diagnostic odds ratio(DOR),specificity,sensitivity,95%CI,the summary receiver operating characteristic(SROC)curve and the area under the curve of ABVS and HHUS.The heterogeneity and publication bias were also evaluated.Results A total of 26 studies were included.Heterogeneity test showed no threshold value effect;random effect model was used to pool specificity,sensitivity and DOR.The pooled sensitivity of ABVS and HHUS was 0.86(95%CI 0.84-0.87),0.80(95%CI 0.78-0.82),respectively;I2 was 89.7% and 82.3%,respectively;the pooled specificity of ABVS and HHUS was 0.91(95%CI 0.90-0.92),0.84(95%CI 0.83-0.86),I2 was 89.7% and 92.2%,respectively.AUC of ABVS,HHUS,and joint diagnosis of the two was 0.954,0.883,0.958,respectively.No evidence of publication bias was shown in the funnel plot analysis.Conclusion ABVS has a higher clinical value compared with HHUS in the diagnosis of benign and malignant breast lesions.
作者
师明莉
张希璘
史丽群
汪江玲
周小会
Shi Mingli;Zhang Xilin;Shi Liqun;Wang Jiangling;Zhou Xiaohui(Department of Physical Diagnosis,Huadong Sanatorium,Wuxi 214065,China;Department of Gynaecology,Huadong Sanatorium,Wuxi 214065,China)
出处
《肿瘤研究与临床》
CAS
2022年第10期774-780,共7页
Cancer Research and Clinic
基金
上海市公共卫生体系三年行动计划及市级财政项目(GWV-7)。
