摘要
目的观察柴葛方对儿童流行性感冒的疗效,及对白细胞介素-6(IL-6)及超氧化物歧化酶(SOD)的影响。方法选取符合表寒里热证流感诊断标准的患儿60例,随机分为观察组及对照组,每组各30例,均予对症治疗,同时观察组予柴葛方口服5d,对照组予奥司他韦口服5d,比较治疗前后两组中医症状积分、血清IL-6及SOD水平,评估其疗效。结果观察组总有效率高于对照组(P<0.05),治疗后观察组中医证候积分明显低于对照组(P<0.01),两组IL-6水平均明显下降,且观察组IL-6比对照组下降更明显(P<0.01)。观察组SOD水平比对照组及治疗前升高(P<0.01)。结论邵氏柴葛方可能通过减低IL-6炎性因子水平,提升SOD活性减轻细胞氧化损伤发挥其抗流感作用,并能有效改善患儿临床症状治疗儿童流感。
Objective To observe the effect of Shao's Chaige prescription on children influenza and the effect of Interleukin-6(IL-6)and superoxide dismutase(SOD).Methods 60 cases of children who met the diagnostic criteria of influenza were randomly divided into the observation group and the control group,with 30 case's in each group.They were all given symptomatic treatment.The observation group was given Shao's Chaige prescription orlly for 5 days,and the control group was given oseltamivir orally for 5 days.TCM symptom scores,serum IL-6 and SOD levels were compared between the two groups before and after treatment to evaluate the efficacy.ResultsThe total effective rate in the observation group was higher than that in the control group(P<0.05),and the TCM syndrome score in the observation group was significantly lower than that in the control group after treatment(P<0.01).IL-6 levels in both groups were significantly decreased,and the IL-6 level in the observation group was more significantly decreased than that in the control group(P<0.o1).SOD level in the observation group was significantly higher than that in the control group and before treatment(P<O.O1).but there was no significant change in control group(P>0.05).Conclusion Shao's Chaige prescription may play an anti-influenza role by reducing the level of IL-6 inflammatory factor,enhancing the activity of SOD and reducing the oxidative damage of cells,and effectively improving the clinical symptoms of children with influenza.
出处
《浙江临床医学》
2022年第11期1669-1671,共3页
Zhejiang Clinical Medical Journal
基金
浙江省中医药科技计划项目(2019ZB091)。
