摘要
目的探讨天麻素注射液与吡咯烷酮类药物联合治疗急性脑出血(ACH)的疗效及对患者氧化应激、神经特异性指标的影响。方法选取2018年6月至2021年2月衢州市中医医院收治的112例ACH患者,将其按随机数字表法分为对照组和观察组,各56例。对照组给予常规治疗联合奥拉西坦治疗,观察组在对照组基础上加用天麻素注射液治疗。比较两组患者脑水肿、脑血肿、神经特异性指标、氧化应激、神经功能、意识状态以及不良反应发生情况。结果治疗后,两组患者脑血肿、脑水肿体积较治疗前明显降低(P<0.05),且观察组明显低于对照组(t=-5.567、-7.836,P<0.05);治疗后,两组患者神经元特异性烯醇化酶(NSE)、丙二醛(MDA)、晚期蛋白氧化产物(AOPP)水平及美国国立卫生研究院卒中量表(NIHSS)评分较治疗前明显降低(P<0.05),且观察组明显低于对照组(t=-4.080、-4.402、-6.093、-5.478,P<0.05),而两组患者脑源性神经营养因子(BDNF)水平及格拉斯哥昏迷量表(GCS)评分较治疗前明显升高(P<0.05),且观察组明显高于对照组(t=-5.864、4.862,P<0.05);两组患者不良反应发生率比较差异无统计学意义(χ^(2)=0.439,P>0.05)。结论天麻素注射液联合奥拉西坦治疗ACH患者可有效缓解患者脑水肿、脑血肿情况,改善患者神经功能及脑意识状态,降低机体氧化应激水平,且疗效具有一定安全性。
Objective To investigate the efficacy of gastrodin injection combined with pyrrolidone in the treatment of acute cerebral hemorrhage(ACH)and its effect on patients'oxidative stress and neuro-specific indicators.Methods A total of 112 ACH patients admitted to Quzhou Hospital of Traditional Chinese Medicine from June 2018 to February 2021 were selected and divided into control group and observation group according to the random number table method,with 56 cases in each.The control group was given conventional treatment combined with oxiracetam,and the observation group was treated with gastrodin injection on the basis of the control group.The occurrence of cerebral edema,cerebral hematoma,nerve specificity,oxidative stress,nerve function,consciousness and adverse reactions of the two groups were compared.Results After treatment,the volume of cerebral hematoma and cerebral edema in the two groups were apparently lower than those before treatment(P<0.05),and those in the observation group were apparently lower than those in the control group(t=-5.567,-7.836;P<0.05).The levels of neuron-specific enolase(NSE),malondialdehyde(MDA),advanced protein oxidation products(AOPP)and the National Institutes of Health Stroke Scale(NIHSS)scores of the two groups were apparently lower than those before treatment(P<0.05),and those in the observation group were apparently lower than those in the control group(t=-4.080,-4.402,-6.093,-5.478;P<0.05).After treatment,the levels of brain-derived neurotrophic factor(BDNF)and Glasgow Coma Scale(GCS)scores of the two groups were apparently higher than those before treatment(P<0.05),and those in the observation group were apparently higher than those in the control group(t=-5.864,4.862;P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.439,P>0.05).Conclusion Gastrodin injection combined with oxiracetam in the treatment of ACH can effectively relieve cerebral edema and cerebral hematoma,improve the patient's neurological function and brain consciousness,and reduce the body's oxidative stress level,and has a certain degree of safety.
作者
姜洪顺
姜国勇
Jiang Hongshun;Jiang Guoyong(Neurosurgery Department,Quzhou Hospital of Traditional Chinese Medicine,Quzhou 324000,China)
出处
《心脑血管病防治》
2022年第5期63-66,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
关键词
天麻素注射液
奥拉西坦
急性脑出血
神经功能
氧化应激
Gastrodin injection
Oxiracetam
Acute cerebral hemorrhage
Nerve function
Oxidative stress
