摘要
目的探索妊娠期糖尿病患者严重程度与尿视黄醇结合蛋白(retinol binding protein,RBP)和血清胱抑素C(cystatin C,CysC)水平的关系。方法选取2017年9月至2018年9月深圳市龙华区人民医院产检的90例妊娠期糖尿病患者为观察组,同期30例健康妊娠妇女为对照组。均进行尿RBP和血清CysC水平检测,比较两组尿RBP和血清CysC水平。然后对妊娠期糖尿病患者进行饮食、运动治疗,分为血糖控制满意组(A组,56例)、血糖控制不满意组(B组,34例),观察其血糖控制程度,比较两组控制前后尿RBP和血清CysC水平变化。结果观察组RBP和CysC水平显著高于对照组(P<0.05),治疗后A、B两组患者RBP和CysC水平较治疗前显著降低(P<0.05)。A组与对照组比较差异无统计学意义(P>0.05),B组RBP和CysC水平高于A组和对照组,差异有统计学意义(P<0.05)。结论检测尿RBP和血清CysC水平对早期判断妊娠期糖尿病的严重程度有重要意义。
Objective To explore the relationship between the severity of gestational diabets mellitus(GDM)and the levels of urinary retinol binding protein(RBP)and serum cystatin C(CysC).Methods To select 90 cases of GDM(observation group)in The People′s Hospital of Longhua Shenzhen from September 2017 to September 2018,and 30 healthy pregnant women(control group)in the same period.Both urine RBP and serum CysC levels were tested,comparing the levels of two groups of urine RBP and serum CysC.Then the diet and exercise treatment of pregnant diabetic patients,divided into blood glucose control satisfaction A group,blood glucose control dissatisfaction B group,observed their blood sugar control degree,compared the two groups before and after treatment of urine RBP and serum CysC level changes.Results RBP and CysC levels were significantly higher in patients with observation groups than in control group(P<0.05),after treatment in group A and group B of patients,RBP and CysC levels were significantly lower than before treatment(P<0.05).The difference in urine RBP and CysC levels between group A and control group was not statistically significant(P>0.05).RBP and CysC levels in group B were higher than those in group A and control group,the differences were statistically significant(P<0.05).Conclusion Testing urine RBP and serum CysC levels is important for early determination of the severity of GDM.
作者
罗小雨
彭菊兰
陆丽
廖湘竹
罗丽琼
LUO Xiaoyu;PENG Julan;LU Li;LIAO Xiangzhu;LUO Liqiong(Department of Obstetrics,The People's Hospital of Longhua,Shenzhen Guangdong 518109,P.R.China)
出处
《中国计划生育和妇产科》
2020年第10期91-93,共3页
Chinese Journal of Family Planning & Gynecotokology
基金
深圳市龙华区科技创新资金项目(项目编号:2017058)。
