摘要
目的探讨美沙拉嗪联合内镜下中药治疗在改善轻中度溃疡性结肠炎(UC)患者炎症状态的应用。方法收集2019年6月至2021年6月就诊的108例UC患者,采用随机对照的研究方法分为观察组和对照组,每组54例。对照组给予美沙拉嗪治疗,观察组给予美沙拉嗪联合自配的健脾化湿中药治疗。比较2组治疗前、后2组患者临床表现、安全性和营养指标及生活质量的变化。结果观察组治疗总有效率为92.58%明显高于对照组的75.93%(P<0.05);2组患者的血清总蛋白(TP)、白蛋白(ALB)、血红蛋白(Hb)、全血红细胞压积(HCT)均较治疗前有明显改善,且观察组改善程度优于对照组(P<0.05);2组患者的IBDQ量表总分及肠道症状、全身症状、情感功能和社会功能评分均较治疗前升高(P<0.05),且观察组升高幅度优于对照组(P<0.05)。结论美沙拉嗪联合内镜下中药治疗对改善轻中度UC具有良好的安全性和疗效,可明显改善患者的营养状态,提高患者的生活质量。
Objective To explore the effect of mesalazine(MSZ)combined with endoscope-assisted traditional Chinese medicine(TCM)in improving the inflammatory state of patients with mild to moderate ulcerative colitis(UC).Methods In a randomized controlled study,UC patients(n=108)in our hospital from June 2019 to June 2021 were enrolled,these patients received either MSZ(n=54,control group)or MSZ+self-prepared TCM of Jianpi Huashi type(n=54,observation group).the clinical manifestation,safety,nutrition indicators,quality-of-life were included as comparator.Results The overall effective rate was higher in the observation group than that in the control group(92.58%vs 75.93%,P<0.05,respectively).After treatment,the serum total protein(TP),albumin(ALB),hemoglobin(Hb),and total hematocrit(HCT)in groups were significantly improved,improvement of which in the observation group were significantly better(P<0.05);the inflammatory bowel disease questionnaire(IBDQ)(Intestinal symptoms,constitutional symptoms,emotional function and social behavior)scores in groups were increased(P<0.05),the observation group was more prevalent(P<0.05).Conclusion For patients with mild to moderate UC,MSZ combined with endoscope-assisted TCM can significantly improve nutritional status,improve quality-of-life,with good safety and efficacy.
作者
董曼
尹平
李炜
杨红梅
董粱
DONG Man;YIN Ping;LI Wei(Department of Gastroenterology,Hengshui People’s Hospital,Hebei,Hengshui 053000,China)
出处
《河北医药》
CAS
2022年第21期3271-3274,共4页
Hebei Medical Journal
基金
河北省医学科学研究重点课题计划(编号:20181593)。
关键词
美沙拉嗪
中药
溃疡性结肠炎
营养状况
生活质量
mesalazine
traditional Chinese medicine
ulcerative colitis
nutritional status
quality of life
