摘要
目的研究矽肺合并慢性阻塞性肺疾病(chronic obstructive pulmoriary disease,COPD)的营养状态调查及流行病学特征。方法以2020年1月至2021年9月在本院进行治疗的120例矽肺患者作为研究对象,根据合并COPD情况,合并组39例,未合并组81例,另选取同期进行健康体检的志愿者120例作为对照组,比较观察组以及对照组、合并COPD组以及未合并COPD组患者的营养状态以及危险因素。结果观察组患者的理想体质量百分比(ideal body weight%,IBW%)(t=84.330,P=0.000)、血清中白蛋白(albumin,ALB)(t=105.496,P=0.000)、外周血总淋巴数(peripheral blood lymphocytes,PBL)(t=45.499,P=0.000)以及上臀中部肌围(mid arm muscle circumference,MAMC)(t=18.438,P=0.000)显著低于对照组,合并COPD组患者的IBW%(t=27.939,P=0.000)、ALB(t=5.462,P=0.000)、PBL(t=56.746,P=0.000)以及MAMC(t=2.548,P=0.012)显著低于未合并COPD组,合并COPD组与未COPD组患者的接尘工龄(t=5.955,P=0.000)、诊断年龄(t=13.013,P=0.000)、接尘到诊断时间(t=2.741,P=0.007)、矽肺分期(χ^(2)=60.330,P=0.000)、吸烟史(χ^(2)=8.215,P=0.004)比较,差异有统计学意义(P<0.05);较高的接尘工龄、诊断年龄、矽肺分期,较低的接尘到诊断时间以及吸烟史均是造成患者合并COPD的危险因素。结论矽肺合并COPD患者的ALB以及MAMC显著降低,较高的接尘工龄、诊断年龄、矽肺分期均是造成患者COPD发生的危险因素。
Objective To study the nutritional status and epidemiological characteristics of silicosis complicated with chronic obstructive pulmoriary disease(COPD).Methods A number of 120 patients with silicosis treated in our hospital from January 2020 to September 2021 were selected as the research objects.According to the situation of COPD,there were 39 cases in the combined group and 81 cases in the non combined group.Another 120 volunteers who underwent physical examination in the same period were selected as the control group.The nutritional status and risk factors of silicosis were compared between observation group and the control group,the combined COPD group and the non combined COPD group.Results Ideal body weight%(IBW%)(t=84.330,P=0.000),albumin(ALB)(t=105.496,P=0.000),peripheral blood lymphocytes(PBL)(t=45.499,P=0.000)and mid arm muscle circumference(MAMC)(t=18.438,P=0.000)in the observation group were significantly lower than those in the control group.IBW%(t=27.939,P=0.000),ALB(t=5.462,P=0.000),PBL(t=56.746,P=0.000)and MAMC(t=2.548,P=0.012)in the COPD group were significantly lower than those in the non COPD group,The difference of the duration of dust exposure(t=5.955,P=0.000),age at diagnosis(t=13.013,P=0.000),time from dust exposure to diagnosis(t=2.741,P=0.007),grade of silicosis(χ^(2)=60.330,P=0.000),and history of smoking(χ^(2)=8.215,P=0.004)between patients with and without COPD was statistically significant(P<0.05);The long duration of dust exposure,older age,high grade of silicosis,short time from dust exposure to diagnosis and history of smoking were risk factors affecting the development of COPD in silicosis patients.Conclusion The serum ALB and MAMC of silicosis patients complicated with COPD decreased significantly.Long dust exposure length of service,diagnosis age,silicosis grade and pulmonary function indexes are the risk factors of COPD.
作者
陆小刚
陆婷
蒋飞
LU Xiao-gang;LU Ting;JIANG Fei(Department of Nutrition,Nantong Second People’s Hospital,Jiangsu 226001,China;不详)
出处
《工业卫生与职业病》
CAS
2022年第5期373-376,共4页
Industrial Health and Occupational Diseases
