摘要
IFIT1是一种高度诱导的具有四肽重复序列的干扰素刺激基因家族(ISGs)成员,主要存在于细胞质,其表达受干扰素(IFN)、多种病毒和某些病原体相关分子模式的调节,具有抗病毒、抗炎等作用。IFIT1的抗病毒作用可通过多种机制和途径发挥,同时部分病毒也进化出独特的机制逃避宿主IFIT1的限制作用,从而对抗机体抗病毒免疫。在许多炎症性疾病中,IFIT1也显示出其独特的抗炎作用。该文就IFIT1的抗炎和抗病毒作用与相关机制作一综述,为进一步研究相关疾病的治疗提供新的靶点和思路。
IFIT1 is a highly inducible member of the interferon stimulating gene family(ISGs)with tetrapeptide repeats.It mainly exists in the cytoplasm and is regulated by interferon,a variety of antiviral role through a variety of mechanisms and pathways,and many viruses have evolved unique mechanisms to evade the limiting effects of IFIT1 and thus counter the body’s antiviral immunity.the unique anti-inflammatory effect of IFIT1 has been extensively studied in inflammatory diseases,Therefore,we mainly review the anti-inflammatory and antiviral effects of IFIT1 and the related mechanisms,so as to provide new therapeutic targets and ideas for the treatment of related diseases.
作者
江伟
陈晓芸
张亚飞
黄成
李俊
王媛媛
JIANG Wei;CHEN Xiao-yun;ZHANG Ya-fei;HUANG Cheng;LI jun;WANG Yuan-yuan(School of Pharmacy,Anhui Medical University,Hefei 230032,China;Dept of Pharmacology,the Second Hospital of Anhui Medical University,Hefei 230601,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第1期5-8,共4页
Chinese Pharmacological Bulletin
基金
安徽省高校协同创新计划(NoGXXT-2019-045)
安徽医科大学校科研基金(No2020xkj190)
白求恩肿瘤临床研究计划项目(NoBCF-XD-ZL-20220118-041)。
关键词
IFIT1
抗炎
抗病毒
干扰素
作用机制
药物治疗
IFIT1
anti-inflammation
antivirus
interferon
mechanism of action
drug therapy
