摘要
目的:观察冠心宁片治疗冠心病不稳定型心绞痛的临床疗效及对心室复极化的影响。方法:按随机抽签法将63例冠心病不稳定型心绞痛患者分为对照组(31例)与试验组(32例)。对照组给予常规西药治疗,试验组在对照组的基础上加用冠心宁片治疗。比较2组治疗前后中医证候积分、QT间期、Tp-e间期、Tp-e/QT比值,并评价2组临床疗效及安全性。结果:对照组脱落1例,试验组脱落2例,最终完成临床研究60例。治疗后,试验组总有效率为93.33%,高于对照组76.67%(P<0.05)。治疗后,2组中医证候积分、QT间期、Tp-e间期、Tp-e/QT比值较治疗前降低(P<0.05),试验组治疗后中医证候积分、Tp-e间期、Tp-e/QT比值改善优于对照组(P<0.05)。2组治疗前后肌酐、谷丙转氨酶、谷草转氨酶水平比较,差异无统计学意义(P>0.05)。结论:冠心宁片联合西药治疗冠心病不稳定型心绞痛疗效确切,能够有效缓解患者心绞痛症状,改善心室复极化,安全性较高。
Objective:To observe the clinical effect of Guanxinning tablets for unstable angina pectoris in coronary heart disease and its effect on ventricular repolarization. Methods:A total of 63 cases of patients with unstable angina pectoris in coronary heart disease were divided into the control group and the experiment group according to the method of random sampling, with 31 and 32 cases in each group respectively. The control group was treated with routine western medicine,and the experiment group was additionally treated with Guanxinning tablets based on the treatment of the control group. Before and after treatment,the Chinese medicine syndrome scores,QT interval,Tp-e interval and Tp-e/QT ratio in the two groups were compared. The clinical effects and safety in the two groups were evaluated. Results:One case in the control group and two cases in the experiment group dropped out. In the end,a total of60 cases were included in the clinical study. After treatment,the total effective rate was 93.33% in the experiment group,higher than that of 76.67% in the control group(P<0.05). After treatment,the Chinese medicine syndrome scores, QT interval, Tp-e interval and Tp-e/QT ratio in the two groups were decreased when compared with those before treatment(P<0.05), and the improvement of the above indexes in the experiment group was better than that in the control group(P<0.05). Before and after treatment, there was no significant difference being found in the comparison of levels of creatinine,alanine aminotransferase and oxaloacetic transaminase between the two groups(P>0.05). Conclusion:Guanxinning tablets combined with western medicine has a definite curative effect in treating unstable angina pectoris in coronary heart disease,which can effectively relieve symptoms of angina pectoris and improve ventricular repolarization with high safety.
作者
陈朋程
于玲欢
项伟忠
CHEN Pengcheng;YU Linghuan;XIANG Weizhong
出处
《新中医》
CAS
2022年第19期84-87,共4页
New Chinese Medicine
基金
浙江省医学会临床科研基金项目(2021ZYC-A238)。
