摘要
目的 回顾性分析持续性心房颤动患者冷冻消融术后应用胺碘酮和美托洛尔的有效性和安全性。方法 从2021年7月至2021年12月,纳入113例接受冷冻消融术的持续性房颤患者,根据术后应用药物的不同,分为胺碘酮组68例和美托洛尔组45例回顾性分析两组的安全性和有效性。结果 胺碘酮组空白期复发的概率低于美托洛尔组(10.3%vs 24.4%,P=0.044)。胺碘酮组术后QT间期较术前显著延长[(423.0±22.5) vs (445.8±22.6),P <0.0001]。胺碘酮组出现甲状腺功能异常的人数多于美托洛尔组,但总体不良反应发生率两组无显著差异。结论 在持续性心房颤动冷冻消融术后3个月的空白期中,应用胺碘酮维持窦律的有效性优于美托洛尔,但术后QT间期较术前明显延长。两者的不良反应发生率相当。
OBJECTIVE To retrospectively analyze the efficacy and safety of amiodarone and metoprolol in patients with persistent atrial fibrillation after cryoablation.METHODS From July 2021 to December 2021,113 patients with persistent atrial fibrillation who underwent cryoablation were enrolled and divided into amiodarone group( n = 68) and metoprolol group( n = 45) according to the different drugs used after surgery.The safety and efficacy of the two groups were retrospectively analyzed.RESULTS The recurrence rate in the amiodarone group was lower than that in the metoprolol group( 10.3% vs 24.4%,P = 0.044).The QT interval in the amiodarone group was significantly longer than that before operation [( 423.0 ± 22.5) vs( 445.8 ± 22.6),P < 0.0001) ].The number of patients with thyroid dysfunction in the amiodarone group was higher than that in the metoprolol group,but there was no significant difference in the overall incidence of adverse reactions between the two groups.CONCLUSION Amiodarone is more effective than metoprolol in maintaining sinus rhythm during the blank period of 3 months after cryoablation for persistent atrial fibrillation,but the postoperative QT interval is significantly longer than that before operation.The incidence of adverse reactions was comparable.
作者
林伟
姜锋
LIN Wei;JIANG Feng(Cadre Health Care Office,Fujian Provincial Hospital,Fuzhou 350001,China)
出处
《海峡药学》
2022年第10期100-103,共4页
Strait Pharmaceutical Journal
关键词
持续性心房颤动
空白期
冷冻消融
胺碘酮
美托洛尔
Persistent Atrial Fibrillation
Blank Period
Cryoablation
Amiodarone
Metoprolol
