摘要
目的探究P21活化激酶5(PAK5)和E-钙黏蛋白(E-cadherin)在肺腺癌组织中的表达及其临床意义。方法采用免疫组织化学方法检测61例肺腺癌组织标本中PAK5以及E-cadherin的表达,并分析PAK5与E-cadherin表达的相关性及与患者临床病理特征和预后的关系。结果61例肺腺癌组织标本中PAK5高表达38例(62.3%),E-cadherin高表达43例(70.5%)。PAK5和E-cadherin的表达水平均与肿瘤T分期、有无淋巴结转移和TNM分期有关(χ^(2)=4.037~16.108,P<0.05),而均与患者的年龄、性别及是否吸烟无关(P>0.05)。PAK5与E-cadherin的表达水平呈负相关(r=-0.355,P<0.05)。PAK5低表达患者3年总生存率和3年无进展生存率均高于高表达患者(χ^(2)=5.893、3.920,P<0.05);E-cadherin高表达患者3年总生存率和3年无进展生存率均高于低表达患者(χ^(2)=5.849、7.363,P<0.05)。结论PAK5高表达和E-cadherin低表达与肺腺癌的浸润、转移及不良预后有关,且PAK5可能通过调控上皮-间质转化促进肺腺癌的进展。
Objective To investigate the expression of P21-activated kinase 5(PAK5)and epithelial cadherin(E-cadhe-rin)in the lung adenocarcinoma(LAC)tissue and its clinical significance.Methods Immunohistochemistry was used to determine the expression of PAK5 and E-cadherin in 61 LAC tissue samples.The correlation between the expression of PAK5 and E-cadherin,as well as their relationship with the clinicopathological characteristics and prognosis of patients with LAC,was analyzed.Results Among the 61 LAC tissue samples,38(62.3%)showed high PAK5 expression and 43(70.5%)showed high E-cadherin expression.The expression levels of PAK5 and E-cadherin were both correlated with T stage,the presence or absence of lymph node metastasis,and TNM stage(χ^(2)=4.037-16.108,P<0.05),and were not correlated with age,sex,and smoking status(P>0.05).PAK5 expression was negatively correlated with E-cadherin expression(r=-0.355,P<0.05).The 3 year overall survival rate and 3 year progression-free survival rate in the low PAK5 expression patients were significantly higher than those in the high PAK5 expression patients(χ^(2)=5.893,3.920,P<0.05);the 3 year overall survival rate and 3 year progression-free survival rate in the high E-cadherin expression patients were significantly higher than those in the low E-cadherin expression patients(χ^(2)=5.849,7.363,P<0.05).Conclusion High PAK5 expression and low E-cadherin expression are associated with invasion,metastasis,and poor prognosis of LAC,and PAK5 may promote the progression of LAC by regulating epithelial-mesenchymal transition.
作者
王雅玲
徐静
赵鹏
孙伟红
彭达
马学真
WANG Yaling;XU Jing;ZHAO Peng;SUN Weihong;PENG Da;MA Xuezhen(Department of Oncology Center,The Second Clinical Medical College of Qingdao University,Qingdao 266042,China)
出处
《精准医学杂志》
2022年第6期502-506,共5页
Journal of Precision Medicine
基金
青岛市应用基础研究计划项目(18-2-2-78-JCH)。
关键词
p21活化激酶类
钙黏着糖蛋白类
上皮-间质转化
肺腺癌
预后
病理状态
体征和症状
p21-Activated kinases
Cadherins
Epithelial-mesenchymal transition
Adenocarcinoma of lung
Prognosis
Pathological conditions,signs and symptoms
