摘要
目的分析卡瑞利珠单抗所致不良反应的临床表现、特点、规律及转归,为临床安全用药提供参考。方法计算机检索自建库至2021年6月PubMed、ScienceDirect、CNKI、VIP以及万方数据库关于卡瑞利珠单抗致不良反应个案报道,采用回顾性研究方法,对纳入病例中患者信息、不良反应发生时间、累及系统、临床表现和转归等进行统计分析。结果共纳入卡瑞利珠单抗不良反应个案报道24篇,共计29例患者。患者平均年龄为(59.34±11.75)岁,女性13例(44.8%),男性16例(55.2%)。不良反应发生时间主要集中在用药后60 d内(23例,79.31%),所致不良反应以皮肤及附件系统(55.17%)、心血管系统(20.69%)、呼吸系统(13.79%)较为多见。结论临床应用卡瑞利珠单抗时特别是前60 d内应加强用药监测,尤其是皮肤及附件系统和心血管系统的不良反应。
Objective To analyze the clinical manifestations,characteristics,regularities and outcomes of adverse drug reactions(ADR)of camrelizumab in order to provide reference for safe use of this drug.Methods Pub Med,Science Direct,CNKI,VIP and WanFang Database were searched for articles on camrelizumab-caused ADRs that were published between the date of inception and June 2021.Using retrospective methods,the information about patients,the time ADRs occurred,systems involved,clinical manifestations,and outcomes were statistically analyzed.Results A total of 24 reports were included,involving 29 patients.The mean age of these patients was(59.34±11.75)years old.There were 13 females(44.8%)and 16 males(55.2%).Most of these ADRs occurred within two months(79.31%)of medication.Camrelizumab-induced ADRs were mostly skin disorders(55.17%),cardiac disorders(20.69%),and respiratory(13.79%)disorders.Conclusion When camrelizumab is used clinically,ADRs should be monitored in the first two months,especially ADRs related to skin systems and cardiac systems.
作者
吴相雷
王慧
杜红丽
胡云英
鲍蕾蕾
WU Xiang-lei;WANG Hui;DU Hong-li;HU Yun-ying;BAO Lei-lei(The Third Affiliated Hospital of Naval Medical University,Shanghai 200438,China)
出处
《解放军药学学报》
CAS
2022年第5期463-467,共5页
Pharmaceutical Journal of Chinese People's Liberation Army
