摘要
外泌体作为“信使”携带蛋白质、核酸、脂质等精微物质,介导细胞间的信号传导转化,在人体脏腑组织间形成精密的细胞调控网络,这与中医传统理论“脾为之使”不谋而合。相关研究发现,病理性外泌体主要通过促进结肠癌转移前微环境的形成进而影响结肠癌转移。本文结合“脾为之使”的再认识,对外泌体的生理功能与“脾为之使”进行相关性分析,从外泌体角度探讨“脾为之使”与结肠癌转移的关系,丰富“脾为之使”的理论内涵,为中医药防治结肠癌转移提供新的研究思路。
As“messengers”,exosomes carry protein,nucleic acids,lipid and other fine substances to mediate the signal transduction and transformation between cells,forming a precise cellular regulatory network in the viscera and tissues of the human body.It is in accordance with the traditional Chinese medicine(TCM)theory of“spleen being the messenger”.Related studies have shown that pathological exosomes affect the metastasis of colon cancer by promoting the formation of pre-metastatic niche.In combination with the re-understanding of“spleen being the messenger”theory,this article analyzes the correlation between the physiological function of exosomes and“spleen being the messenger”as well as the relationship between“spleen being the messenger”and the metastasis of colon cancer from the perspective of exosomes,which enriches the theoretical connotation of“spleen being the messenger”and provides new research ideas for the prevention and treatment of metastasis of colon cancer in TCM.
作者
李巧
肖冲
由凤鸣
祝捷
金钊
严然
LI Qiao;XIAO Chong;YOU Fengming;ZHU Jie;JIN Zhao;YAN Ran(Affiliated Hospital,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Cancer Institute,Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)
出处
《空军军医大学学报》
CAS
2022年第7期907-909,913,共4页
Journal of Air Force Medical University
基金
国家自然科学基金面上项目(82074315)
四川省中医药重点学科建设项目(2100601)。
关键词
脾为之使
外泌体
转移前微环境
结肠癌转移
spleen being the messenger
exosomes
pre-metastatic niche
metastasis of colon cancer
