摘要
目的探讨李氏砭法刮痧治疗急性湿疹的效果。方法选取2019年6月至2021年6月于广州中医药大学深圳医院就诊的77例急性湿疹患者作为研究对象,采用电脑随机数字表法将其分为观察组(38例)、对照组(39例)。观察组患者采用李氏砭法刮痧治疗,对照组患者采用口服氯雷他定片、外用曲安奈德益康唑乳膏治疗。两组患者均连续治疗3周。比较两组患者治疗前后的湿疹面积及严重程度指数(EASI)评分及血清白细胞介素-5(IL-5)、白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)、白细胞介素-2(IL-2)水平;比较两组患者的临床疗效;比较两组的不良反应总发生率;比较两组患者的复发率。结果两组患者治疗前的EASI评分、血清IL-5、IL-4、IFN-γ、IL-2水平比较,差异均无统计学意义(P>0.05);两组患者治疗后的EASI评分均低于治疗前,且观察组患者治疗后的EASI评分低于对照组,差异有统计学意义(P<0.05);两组患者治疗后的血清IL-5、IL-4水平均低于治疗前,且观察组患者治疗后的血清IL-5、IL-4水平均低于对照组,差异有统计学意义(P<0.05);两组患者治疗后的血清IFN-γ、IL-2水平均高于治疗前,且观察组患者治疗后的血清IFN-γ、IL-2水平均高于对照组,差异有统计学意义(P<0.05)。观察组患者的总有效率高于对照组,差异有统计学意义(P<0.05)。在治疗过程中,观察组患者的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。治疗结束1个月后电话随访,观察组患者的复发率低于对照组,差异有统计学意义(P<0.05)。结论李氏砭法刮痧能够更好地调节急性湿疹患者细胞因子的紊乱状态,改善症状,具有疗效显著、不良反应少、复发率低等优点,值得临床推广应用。
Objective To evaluate the efficacy of Li's bian stone scraping in the treatment of acute eczema.Methods A total of 77 patients with acute eczema admitted to Shenzhen Hospital of Guangzhou University of Chinese Medicine from June 2019 to June 2021 were recruited as subjects and divided into the observation group(n=38)and control group(n=39)by computer random number table method.In the observation group,Li's bian stone scraping was delivered,and in the control group,oral intake of Loratadine Tablets and topical use of Triamcinolone Acetonide Econazole Cream were given.Both groups were treated for 3 weeks.The eczema area and severity index(EASI)score and serum levels of interleukin-5(IL-5),IL-4,interferon-γ(IFN-γ)and IL-2 before and after treatment were compared between two groups.Clinical efficacy was assessed between two groups.The incidence of adverse reactions and recurrence rate were compared between two groups.Results There were no significant differences in EASI score,serum levels of IL-5,IL-4,IFN-γand IL-2 between the two groups before treatment(P>0.05).The EASI scores of the two groups after treatment were lower than those before treatment,and the EASI score of the observation group after treatment was lower than that of the control group,and the differences were statistically significant(P<0.05).The serum levels of IL-5 and IL-4 in the two groups after treatment were lower than those before treatment,and the serum levels of IL-5 and IL-4 in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).The serum levels of IFN-γand IL-2 in the two groups after treatment were higher than those before treatment,and the serum levels of IFN-γand IL-2 in the observation group after treatment were higher than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).During the treatment,the total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).One month after the end of treatment,the recurrence rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Li's bian stone scraping can effectively regulate the cytokine disorder and mitigate relevant symptoms.It yields high clinical efficacy,slight adverse reactions and low recurrence rate,which is worthy of application in clinical practice.
作者
吴玉娟
李道政
郑盛惠
WU Yujuan;LI Daozheng;ZHENG Shenghui(Traditional Chinese Medicine Comprehensive Treatment Area,Shenzhen Hospital of Guangzhou University of Chinese Medicine,Guangdong Province,Shenzhen 518034,China)
出处
《中国当代医药》
CAS
2022年第31期175-179,共5页
China Modern Medicine
