摘要
目的回顾性分析陈氏调经汤联合芬吗通治疗肝肾阴虚型卵巢早衰的临床疗效。方法对2019年1月—2021年1月浙江中医药大学附属第三医院收治的40例肝肾阴虚型卵巢早衰患者进行回顾性分析,根据治疗方法分为芬吗通治疗组(对照组,17例)及芬吗通联合陈氏调经汤治疗组(观察组,23例),6个月后观察治疗效果。结果治疗后,观察组各项中医证候积分均低于对照组(均P<0.05);观察组治疗效果优于对照组(Z=-2.455,P<0.05);观察组血清促卵泡生成素(FSH)、黄体生成素(LH)水平[(19.21±4.57)IU/L、(20.44±3.10)IU/L]低于对照组[(22.78±4.69)IU/L、(23.17±3.44)IU/L,均P<0.05];观察组雌二醇(E_(2))水平为(69.22±12.39)pmol/L,高于对照组[(60.98±11.22)pmol/L,P<0.05];观察组卵巢体积、窦卵泡数(AFC)、卵巢动脉收缩期峰值血流速度(PSV)高于对照组,阻力指数(RI)、加速时间(TA)低于对照组(均P<0.05)。结论陈氏调经汤联合芬吗通治疗肝肾阴虚型卵巢早衰疗效显著,可有效缓解临床症状,促进性激素水平恢复,改善卵巢功能。
Objective To retrospectively analyses the clinical curative effect of Chen's Menstrual Conditioning Soup combined with femoston on premature ovarian failure of liver and kidney Yin deficiency syndrome.Methods Forty cases of premature ovarian failure with Yin deficiency of liver and kidney in the Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine were retrospectively analysed from January 2019 to January 2021.According to the treatment methods,they were divided into femoston treatment group(control group,n=17)and femoston combined with Chen's Menstrual Conditioning Soup treatment group(observation group,n=23).The treatment effect was observed after 6 months.Results After treatment,the scores of TCM syndromes in the observation group were lower than those in the control group(all P<0.05).The therapeutic effect of the observation group was better than that of the control group(Z=-2.455,P<0.05).The levels of serum follicle stimulating hormone and luteinizing hormone in the observation group were(19.21±4.57)IU/L and(20.44±3.10)IU/L,respectively,which were lower than those in the control group[(22.78±4.69)IU/L,(23.17±3.44)IU/L,all P<0.05].The level of estradiol(E_(2))in the observation group was(69.22±12.39)pmol/L,which was higher than that in the control group[(60.98±11.22)pmol/L,P<0.05].The mean ovarian volume,number of antral follicles and peak systolic blood flow velocity of ovarian artery in the observation group were higher than those in the control group,and the resistance index and acceleration time were lower than those in the control group(all P<0.05).Conclusion Chen's Menstrual Conditioning Soup combined with femostone has a remarkable effect on premature ovarian failure of liver and kidney Yin deficiency syndrome,and it can effectively alleviate clinical symptoms,promote the recovery of sex hormone level and improve ovarian function.
作者
张文瑜
吴欢
ZHANG Wen-yu;WU Huan(Department of Gynecology,the Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou,Zhejiang 310005,China;不详)
出处
《中华全科医学》
2022年第11期1934-1937,共4页
Chinese Journal of General Practice
基金
浙江省教育厅一般科研项目(Y201942331)
浙江省中医药科技计划项目(2019ZB066)。
关键词
陈氏调经汤
芬吗通
肝肾阴虚型卵巢早衰
性激素水平
Chen's Menstrual Conditioning Soup
Femoston
Premature ovarian failure of liver and kidney Yin deficiency syndrome
Sex hormone levels
