摘要
背景:镁合金材料依靠其优良的生物相容性和可降解性被誉为“革命性的金属材料”,其降解对内皮化的影响具有重大研究意义。目的:综述镁合金材料的研究进展。方法:利用计算机检索PubMed、中国知网数据库、Web of Science和Elsevier等数据库中的相关文献,以“金属生物材料,镁合金材料,血管支架,内皮化,动物实验,体外实验”为中文主题检索词,以“Metallic biomaterials,Magnesium alloys,Vascular stents,Endothelialization,Animal experiments,In vitro”为英文检索词进行检索,检索时限为2015-2022年,通过阅读文题和摘要进行初步筛选,最终纳入116篇文献进行结果分析。结果与结论:镁合金材料降解形成的含一定浓度镁离子的微环境有利于内皮细胞及平滑肌细胞的增殖,镁离子对内皮化的作用基本被认可。但降解速率过快是镁合金的最大问题,镁离子浓度过高会出现细胞毒性,因此目前的研究多集中于改善其降解,提高生物相容性。目前常见的改善镁合金降解的方法有纯化、合金化、表面改性,均可提高其耐腐蚀性,并且不同元素的合金化对镁合金的改善是不同方面,未来可能针对不同需求来选择不同合金化的镁合金以适应临床患者的情况,除引入其他元素外,改进镁合金的制作工艺改善降解问题也可能是一种值得尝试的方法。
BACKGROUND:Magnesium alloys have been known as the revolutionary metallic materials because of their excellent biocompatibility and degradability.The effect of its degradation on endothelialization has great research significance.OBJECTIVE:To review the research progress of magnesium alloy materials.METHODS:The articles were searched by using the databases of PubMed,CNKI,Web of Science,and Elsevier.The key words were“Metallic biomaterials,Magnesium alloys,Vascular stents,Endothelialization,Animal experiments,In vitro”in Chinese and English.As a result,116 articles were applied after reading and analyzing the titles and abstracts of the articles published between 2015 and 2022.RESULTS AND CONCLUSION:Appropriate concentrations of magnesium ions can enhance the proliferation of endothelial cells and smooth muscle cells during the degradation of magnesium alloys.The effect of magnesium ions on endothelialization is basically recognized.Nevertheless,too fast degradation rate is the biggest problem of magnesium alloys.If the concentration of magnesium ions is too high,cytotoxicity will occur.Therefore,current studies mostly focus on improving its degradation and improving its biocompatibility.At present,the common methods to improve the degradation of magnesium alloys include purification,alloying and surface modification,all of which can improve their corrosion resistance.The alloying of different elements can improve magnesium alloys in different ways.In the future,different alloyed magnesium alloys can be used according to different needs to adapt to the situation of clinical patients.In addition to introducing other elements,improving the production process of magnesium alloys to solve the degradation problem may also be a method worth trying.
作者
董士武
周岚曦
邵路
喻正文
Dong Shiwu;Zhou Lanxi;Shao Lu;Yu Zhengwen(School of Stomatology,Zunyi Medical University,Zunyi 563099,Guizhou Province,China;Key Laboratory of Oral Disease Research of Department of Guizhou Education,Zunyi 563099,Guizhou Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2023年第21期3398-3406,共9页
Chinese Journal of Tissue Engineering Research
基金
贵州省科技计划项目(黔科合平台人才[2017]5733-057),项目负责人:喻正文
贵州省医用生物材料研发人才基地(黔人领发[2018]3号),项目参与者:喻正文。
关键词
金属生物材料
镁合金材料
血管支架
内皮化
动物实验
体外实验
metal biomaterial
magnesium alloy material
vascular stent
endothelialization
animal experiment
in vitro experiment
