摘要
目的通过对ABO血型不合、Rh血型不合及不明原因三组新生儿高胆红素血症患儿换血前后的相关实验室指标进行对比分析,为安全换血及后续输血治疗提供指导。方法收集我院2017年1月~2021年12月实施换血治疗的35例新生儿溶血病的患儿临床资料,对比分析三组换血前后血红蛋白、血清总胆红素等各指标差异。结果换血前,Rh血型不合组的血红蛋白、血清总胆红素均低于不明原因黄疸组;换血后24 h和48 h,Rh血型不合组的血清总胆红素均高于ABO血型不合组和不明原因黄疸组。不同病因的高胆红素血症患儿换血治疗后的血红蛋白值和血清总胆红素值差异有统计学意义(P<0.05)。结论不同病因的新生儿高胆红素血症的发病机制不同,换血后的血红蛋白、总胆红素改善情况也不同。
Objective To provide guidelines for safe exchange transfusion and subsequent transfusion treatment,we compared three groups of laboratory indexes before and after exchange transfusion,i.e.ABO blood type incompatibility,Rh blood type incompatibility and unexplained neonatal hyperbilirubinemia.Methods Thirty-five cases of newborns undergoing exchange transfusion in our hospital from January 2017 to December 2021 were selected,and the laboratory indexes including hemoglobin and serum total bilirubin were analyzed before and after exchange transfusion.Results Before exchange transfusion,the hemoglobin and serum total bilirubin levels in the Rh blood type incompatibility group were lower than those of the unexplained hyperbilirubinemia group.However,24 h or 48 h after exchange transfusion,the serum total bilirubin level was higher in the Rh blood type incompatibility group than in the ABO blood type incompatibility group and the unexplained jaundice group.There were significant differences in hemoglobin and serum total bilirubin among different types of neonatal hyperbilirubinemia posttransfusion(P<0.05).Conclusion The pathogenesis of hyperbilirubinemia and the posttransfusion levels of hemoglobin and total bilirubin seem to vary with different types of neonates with this disease.
作者
陈娟
黄蓉
胡文静
CHEN Juan;HUANG Rong;HU Wen-jing(Women's Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing 210004)
出处
《临床输血与检验》
CAS
2022年第5期596-599,共4页
Journal of Clinical Transfusion and Laboratory Medicine
关键词
新生儿
高胆红素血症
换血疗法
Neonate
Hyperbilirubinemia
Exchange transfusion therapy
