摘要
Dear Editor,Wound healing after tissue injury is a well-orchestrated process involving various cell types,growth factors,and extracellular matrix(ECM)components.Collagen triple helix repeat containing1(CTHRC1),a secreted ECM protein,is transiently expressed in the repair process after arterial injury and myocardial infarction,1 regulating collagen matrix deposition and cell migration through TGF-βsignaling pathway.2 However,the expression and function of CTHRC1 during cutaneous wound repair remain largely undefined.We initially investigated the spatiotemporal expression of CTHRC1 during full-thickness cutaneous wound healing.By searching the GEO database,we found a transcriptome dataset(GSE23006),which analyzed the gene expression of mouse skin wounds from day 0 to day 10,spanned all stages of the wound healing process.
基金
supported in part by the National Natural Science Foundation of China(81830064,81721092,32000969,82002056)
Key Support Program for Growth Factor Research(SZYZ-TR-03)
Chinese PLA General Hospital for Military Medical Innovation Research Project(CX-19026)
the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-059)
the Military Medical Research and Development Projects(AWS17J005)
Beijing Natural Science Foundation(7204306)。
