摘要
目的:研究布地奈德雾化吸入联合阿奇霉素序贯疗法治疗儿童肺炎支原体(MP)感染的效果。方法:选取2020年5月-2021年5月当阳市人民医院收治的98例MP感染患儿。按照随机数字表法将其分为序贯疗法组和联合治疗组,各49例。序贯疗法组给予阿奇霉素注射液序贯疗法治疗,联合治疗组给予布地奈德雾化吸入联合阿奇霉素序贯疗法治疗。比较两组康复时间,治疗前及治疗15 d后免疫功能及炎症因子,不良反应。结果:联合治疗组喘咳消失、退热、肺啰音消失时间均明显早于序贯疗法组(P<0.05)。治疗15 d后,联合治疗组IgM、IgA、IL-2、INF-γ水平均显著低于序贯疗法组(P<0.05)。治疗15 d内两组胃肠道反应、皮疹、支气管痉挛发生率比较差异均无统计学意义(P>0.05)。结论:布地奈德雾化吸入联合阿奇霉素序贯疗法治疗儿童MP感染可缓解患儿临床症状和炎症水平,恢复其免疫功能,且安全性良好。
Objective:To study the effect of Budesonide atomization inhalation combined with Azithromycin sequential therapy in the treatment of mycoplasma pneumoniae (MP) infection in children.Method:A total of 98 children with MP infection admitted to Dangyang People’s Hospital from May 2020 to May 2021 were selected.According to the random number table method,they were divided into sequential therapy group and combined therapy group,with 49 cases in each group.The sequential therapy group was given Azithromycin Injection sequential therapy treatment,and the combined therapy group was given Budesonide atomization inhalation combined with Azithromycin sequential therapy.The recovery time,immune function,inflammatory factors before and after 15 days of treatment and adverse reactions were compared between the two groups.Result:The time of disappearance of asthma and cough,antipyretic time and time of disappearance of lung rales in the combined therapy group were significantly earlier than those in the sequential therapy group (P<0.05).After 15 days of treatment,the levels of immunoglobulin M (IgM),immunoglobulin A (IgA),interleukin-2 (IL-2),interferon-γ (INF-γ) in the combined therapy group were significantly lower than those in the sequential therapy group (P<0.05).There were no significant differences in the incidences of gastrointestinal reaction,rash and bronchospasm between the two groups within 15 days of treatment (P>0.05).Conclusion:Budesonide atomization inhalation combined with Azithromycin sequential therapy in the treatment of MP infection in children can relieve the clinical symptoms and inflammation level of children,restore their immune function,and have good safety.
作者
黄艳春
张琼
HUANG Yanchun;ZHANG Qiong(Dangyang People’s Hospital,Dangyang 444100,China)
出处
《中外医学研究》
2022年第27期135-138,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
布地奈德
阿奇霉素序贯疗法
肺炎支原体感染
疗效
Budesonide
Azithromycin sequential therapy
Mycoplasma pneumoniae infection
Curative effect
