摘要
目的:初步探讨特发性肺纤维化急性加重期(AE-IPF)和结缔组织病相关性间质性肺病急性加重期(AE-CTD-ILD)证候及证素分布异同规律,为中医药诊治提供参考。方法:采用回顾性病例对照研究,基于河南中医药大学第一附属医院电子病历系统,收集近5年住院的AE-IPF和AE-CTD-ILD患者一般信息、四诊信息及中医证候。采用SPSS25.0统计软件分析比较AE-IPF和AE-CTD-ILD中医四诊资料及证候、证素,探讨总结AE-IPF或AE-CTD-ILD证候、证素的分布规律及差异。结果:共纳入186例患者,AE-IPF患者52例,男性36例,女性16例,平均年龄(62.71±7.442)岁;AECTD-ILD患者134例,男性33例,女性101例,平均年龄(57.63±9.765)岁。两组性别及年龄分布差异均具有统计学意义(P<0.01)。在证候分布方面,两组患者中均以肺肾气阴两虚证占比最多,其中AE-IPF患者32例(61.5%),AE-CTD-ILD患者29例(21.6%),差异具有统计学意义(P<0.01);在证素分布上,AE-IPF以阴虚为主(34例,65.4%),与AE-CTD-ILD(46例,34.3%)相比,两者差异具有统计学意义(P<0.01)。结论:AE-IPF和AE-CTD-ILD患者证型和证素分布存在差异。在证候分布及证素分布上,AE-IPF与AE-CTD-ILD患者相比均更偏于阴虚,临床治疗时可适当参以养阴之品,以提高临床疗效。
Objective:To explore the similarities and differences in the distribution of syndromes and syndrome elements of acute exacerbation of idiopathic pulmonary fibrosis(AE-IPF)and acute exacerbation of connective tissue disease associated interstitial lung disease(AE-CTD-ILD),so as to provide reference for the diagnosis and treatment of the diseases.Methods:A retrospective case-control study was used to collect the general information,four diagnostic information and TCM syndromes of the patients with AE-IPF and AE-CTD-ILD hospitalized in recent 5 years based on the electronic medical record system of The First Affiliated Hospital of Henan University of Chinese Medicine.SPSS25.0 statistical software was used to analyze and compare the four diagnostic data,syndromes and syndrome elements of AE-IPF and AE-CTD-ILD,and to explore and summarize the distribution rules and differences of syndromes and syndrome elements of AE-IPF or AE-CTD-ILD.Results:A total of 186 patients were included,including 52 patients with AE-IPF,36 males and 16 females,with an average age of(62.71±7.442)years old;There were 134 patients with AE-CTD-ILD,33 males and 101 females,with an average age of(57.63±9.765)years old.There were significant differences in gender and age distribution between the two groups(P<0.01).In terms of syndrome distribution,both Qi and Yin deficiency of Lung and Kidney dominated in the two groups,including32 patients with AE-IPF(61.5%)and 29 patients with AE-CTD-ILD(21.6%),the difference between them was statistically significant(P<0.01).In terms of the distribution of syndrome elements,AE-IPF was mainly dominated by Yin deficiency(34 cases,65.4%),which was statistically significant compared with AE-CTD-ILD(46 cases,34.3%)(P<0.01).Conclusion:There are differences in the distribution of syndrome patterns and syndrome elements between patients with AE-IPF and patients with AE-CTD-ILD.In terms of syndrome distribution and syndrome element distribution,AE-IPF is more inclined to Yin deficiency than AE-CTD-ILD,therefore Yin nourishing products can be properly used in clinical treatment to improve clinical efficacy.
作者
刘梦洋
张铭铭
杨曙光
洪赟晢
余学庆
LIU Mengyang;ZHANG Mingming;YANG Shuguang;HONG Yunzhe;YU Xueqing(Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《中医药学报》
CAS
2022年第10期76-82,共7页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金项目(81973779)
中原千人计划-中原科技创新领军人才项目(194200510018)
河南省科技攻关计划(182102311165)
河南省中医管理局国家中医临床研究基地业务建设科研专项(2018JDZX006)。
关键词
特发性肺纤维化
结缔组织病相关性间质性肺病
急性加重期
中医证候
证素
Idiopathic pulmonary fibrosis
Connective tissue disease associated interstitial lung disease
Acute exacerbation period
TCM syndrome
Syndrome element
