摘要
目的观察玉屏风颗粒联合布地奈德福莫特罗粉吸入剂治疗支气管哮喘(肺气虚型)的疗效观察其对炎性因子水平、免疫功能、肺功能的影响。方法将120例支气管哮喘患者随机分为观察组和对照组各60例。对照组予地奈德福莫特罗粉吸入剂,1吸/次,2次/d,治疗2周。在对照组基础上加用玉屏风颗粒,1袋/次,3次/d,开水冲服,治疗2周。比较两组治疗后临床疗效;治疗前后炎症因子水平,包括肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4);免疫功能包括免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+);肺功能,包括用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、FEV_(1)占用力肺活量的比值(FEV_(1)/FVC)。结果治疗后,观察组总有效率高于对照组(P<0.05);两组IL-2、IL-4、TNF-α均降低(P<0.05),观察组均低于对照组(P<0.05);两组CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、IgA、IgG均提高,CD_(8)^(+)降低(P<0.05),观察组CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、IgA、IgG均高于对照组观,CD_(8)^(+)低于对照组(P<0.05);两组FVC、FEV_(1)、FEV_(1)/FVC均升高(P<0.05),观察组FVC、FEV_(1)、FEV_(1)/FVC均高于对照组(P<0.05)。结论玉屏风颗粒联合布地奈德福莫特罗粉吸入剂治疗支气管哮喘(肺气虚型)可提高临床疗效,减轻炎性反应,提高机体免疫力,提高肺功能,值得推广。
Objective To observe the efficacy of Yupingfeng Granule(玉屏风颗粒)combined with budesonide formoterol powder inhalation in the treatment of bronchial asthma(Feqixu)and its effects on inflammatory factor level,immune function and lung function.Methods 120 patients were randomly divided into observation group and control group.The control group was given desnide formoterol powder inhaler,once,twice a day for 2 weeks.On the basis of the control group,Yupingfeng granules were added,1 bag/time,3 times/d,washed with boiled water for 2 weeks.The clinical effects of the two groups were compared;the levels of inflammatory factors,including tumor necrosis factor,were compared between the two groups before and after treatment,TNF-α,IL-2,IL-4;immune function includes immunoglobulin A(IGA),immunoglobulin G(IgG),CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+);pulmonary function,including forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1)),and the ratio of FEV_(1) to forced vital capacity(FEV_(1)/FVC).Results After treatment,the total effective rate in the observation group was higher(P<0.05),IL-2,IL-4 and TNF-α all decreased(P<0.05),and the observation group was lower than the control group(P<0.05);CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+),IgA and IgG in the two groups increased and CD_(8)^(+)decreased(P<0.05).CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+),IgA and IgG in the observation group were higher,the CD_(8)^(+)was lower(P<0.05);FVC,FEV_(1) and FEV_(1)/FVC increased in the two groups(P<0.05),and FVC,FEV_(1) and FEV_(1)/FVC in the observation group were higher(P<0.05).Conclusion Yupingfeng granule combined with budesonide formoterol powder inhalation in the treatment of bronchial asthma(Feqixu)can improve clinical efficacy,reduce inflammatory reaction,improve body immunity and improve lung function,which is worthy of popularization.
作者
方秀云
董士佳
FANG Xiuyun;DONG Shijia(Gucheng Hospital Affiliated to Hubei University of Arts and Sciences,Gucheng 441700,Hubei,China)
出处
《实用中医内科杂志》
2022年第8期86-88,共3页
Journal of Practical Traditional Chinese Internal Medicine
基金
湖北省卫生健康委员会科研项目(WJ2019F086)。
关键词
支气管哮喘
玉屏风颗粒
地奈德福莫特罗粉吸入剂
炎性因子
免疫功能
肺功能
bronchial asthma
Yupingfeng granule(玉屏风颗粒)
dexamethasone formoterol powder inhaler
inflammatory factors
immunity
pulmonary function
