摘要
目的探究3.0T磁共振成像(MRI)扫描参数与宫颈癌患者肿瘤标志物的相关性及诊断价值。方法回顾性选取2019年1月至2020年3月恩施土家族苗族自治州中心医院收治的159例疑似宫颈癌患者作为研究对象,将其中经病理学诊断最终确诊宫颈癌的118例患者纳入观察组,其他41例患者纳入对照组。对所有患者行3.0T MRI检查,并采用酶联免疫吸附试验(ELISA)检测肿瘤标志物[鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)、糖链抗原199(CA199)、细胞角蛋白21-1(CYFRA21-1)]水平。对比两组MRI扫描参数,分析宫颈癌患者MRI扫描参数与肿瘤标志物水平的相关性及各指标与病理分期诊断的相关性,分析MRI扫描参数对宫颈癌的诊断价值。结果与对照组相比,观察组最大相对增强率(MRE)、表观弥散系数(ADC)水平较低,达峰时间(TTP)缩短(P<0.05)。与Ⅰ期、Ⅱ期、Ⅲ期宫颈癌患者相比,Ⅳ期宫颈癌患者MRE、ADC、CA199、CEA、CYFRA21-1、SCC-Ag水平较高,TTP水平较低(P<0.05)。宫颈癌患者MRE、ADC、CA199、CEA、CYFRA21-1、SCC-Ag水平与病情严重程度呈正相关,TTP水平呈负相关(P<0.05)。MRE、TTP、ADC三项联合可提高宫颈癌的诊断效能(P<0.05)。结论MRI扫描参数与宫颈癌患者肿瘤标志物水平具有一定相关性,并对宫颈癌患者病理分期诊断具有一定的诊断价值。
Objective To explore the correlation and diagnostic value of 3.0T magnetic resonance imaging(MRI)scan parameters and tumor markers in patients with cervical cancer.Methods A total of 159 suspected cervical cancer patients admitted to Central Hospital of Enshi Tujia and Miao Autonomous Prefecture from January 2019 to March 2020 were retrospectively selected.118 patients with cervical cancer confirmed by postoperative pathological examination were included in the observation group,and the rest of 41 patients were included in the control group.3.0T MRI detection was performed on all patients,and the levels of squamous cell carcinoma antigen(SCC-Ag),carcino-embryonic antigen(CEA),carbohydrate antigen 199(CA199)and cytokeratin 19 fragment antigen 21-1(CYFRA21-1)of all subjects were detected by enzyme linked immunosorbent assay(ELISA)and compared.MRI scan parameters of the two groups were compared to analyze the correlation between MRI scan parameters of cervical cancer patients and the level of tumor markers as well as the correlation between each index and the diagnosis of disease stage,and to analyze the diagnostic value of MRI scan parameters for cervical cancer.Results Compared with the control group,the maximum relative enhancement rate(MRE)and apparen dispersion coefficient(ADC)levels were lower in the observation group,and peak time(TTP)was shorter in the observation group(P<0.05).Compared with patients with stageⅠ,ⅡandⅢcervical cancer,the levels of MRE,ADC,CA199,CEA,CYFRA21-1 and SCC-Ag were higher in patients with stageⅣcervical cancer,and the levels of TTP were lower(P<0.05).The levels of MRE,ADC,CA199,CEA,CYFRA21-1 and SCC-Ag were positively correlated with the severity of cervical cancer,while TTP levels were negatively correlated(P<0.05).The combination of MRE,TTP and ADC could improve the diagnostic efficiency of cervical cancer(P<0.05).Conclusions MRI scan parameters are correlated with the level of tumor markers in patients with cervical cancer,which has certain diagnostic value for the diagnosis of disease staging in patients with cervical cancer.
作者
黄治华
赵慧艳
HUANG Zhihua;ZHAO Huiyan(Department of Radiology,Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi 445000,Hubei,China)
出处
《中国性科学》
2022年第8期74-77,共4页
Chinese Journal of Human Sexuality
基金
湖北省自然科学基金项目(2019FFC117)。
关键词
磁共振成像
宫颈癌
肿瘤标志物
细胞角蛋白21-1
Magnetic resonance imaging
Cervical cancer
Tumor markers
Cytokeratin 19 fragment antigen 21-1
