摘要
目的系统评价补阳还五汤治疗急性脑梗死气虚血瘀证的用药安全性和临床疗效。方法检索中国期刊全文数据库(CNKI)、万方数据库、维普数据库(VIP)、读秀、PubMed、EMbase、the Cochrane Library,时间为建库至2020年12月。选择符合纳入标准和排除标准的相关文献,筛选符合标准的随机对照试验,采用RevMan 5.4软件评价纳入文献的风险偏倚和Meta分析。结果共纳入29项研究。Meta分析结果显示,试验组临床总有效率[RR=1.21,95%CI(1.16,1.25),P<0.00001],神经功能缺损评分[SMD=-1.32,95%CI(-1.56,-1.08),P<0.00001],日常生活活动能力(Barthel Index)[SMD=1.92,95%CI(1.14,2.70),P<0.00001],中医证候疗效[RR=1.21,95%CI(1.08,1.36),P=0.001],肢体运动功能(FMA)[SMD=6.32,95%CI(4.10,8.54),P<0.00001],全血高切黏度[SMD=-0.74,95%CI(-1.06,-0.41),P<0.0001],全血低切黏度[SMD=-1.30,95%CI(-1.78,-0.82),P<0.00001],血浆黏度[SMD=-1.74,95%CI(-2.24,-1.24),P<0.00001],纤维蛋白原[SMD=-0.59,95%CI(-0.81,-0.38),P<0.00001],不良反应[RR=0.53,95%CI(0.32,0.88),P=0.01]均优于对照组。结论现有证据表明,补阳还五汤治疗急性脑梗死气虚血瘀证可改善病人临床疗效、神经功能缺损和肢体运动功能,同时提高日常生活活动能力,不良反应率低。
Objective To systematically evaluate the safety and clinical efficacy of Buyang Huanwu Decoction in the treatment of acute cerebral infarction with Qi deficiency and blood stasis syndrome.Methods China Journal Full-Text Database(CNKI),WanFang Database,VIP database,Duxiu,PubMed,EMbase,and the Cochrane Library were searched from the establishment to December 2020.Relevant literatures that met the inclusion and exclusion criteria were selected,randomized controlled trials that met the criteria were screened.The Cochrane were used for risk assessment,and RevMan 5.4 software was used for Meta-analysis.Results A total of 29 literatures were included.The results of Meta-analysis showed that the total clinical efficacy[RR=1.21,95%CI(1.16,1.25),P<0.00001],neurological deficit score[SMD=-1.32,95%CI(-1.56,-1.08),P<0.00001],activities of daily living(Barthel Index)[SMD=1.92,95%CI(1.14,2.70),P<0.00001],evaluation of traditional Chinese medicine syndrome efficacy[RR=1.21,95%CI(1.08,1.36),P=0.001],limb motor function(FMA)[SMD=6.32,95%CI(4.10,8.54),P<0.00001],whole blood high shear viscosity[SMD=-0.74,95%CI(-1.06,-0.41),P<0.0001],whole blood low shear viscosity[SMD=-1.30,95%CI(-1.78,-0.82),P<0.00001],plasma viscosity[SMD=-1.74,95%CI(-2.24,-1.24),P<0.00001],fibrinogen[SMD=-0.59,95%CI(-0.81,-0.38),P<0.00001],and adverse reactions[RR=0.53,95%CI(0.32,0.88),P=0.01]of the experimental group were better than those of the the control group.Conclusion The Current evidence showed that Buyang Huanwu Decoction in the treatment of acute cerebral infarction with Qi deficiency and blood stasis syndrome could improve clinical efficacy,neurological deficit and limb motor function,and improve activities of daily living,with low adverse reaction rate.
作者
任润雪
范文涛
REN Runxue;FAN Wentao(Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China)
出处
《中西医结合心脑血管病杂志》
2022年第16期2904-2913,共10页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
国家自然科学基金项目(No.81673832)。
关键词
急性期脑梗死
补阳还五汤
气虚血瘀证
神经功能
META分析
acute cerebral infarction
Buyang Huanwu Decoction
Qi deficiency and blood stasis syndrome
neurological function
Meta-analysis
