摘要
目的 探究辅助性T17细胞/调节性T细胞(Th17/Treg)炎性细胞因子对自身免疫性疾病(AID)合并重症肺部感染的病情评估价值。方法 以2010年3月-2020年7月武汉市长江航运总医院80例AID合并肺部感染患者为研究组,同期AID患者50例为对照组,比较两组患者Th17/Treg炎性细胞因子[白细胞介素(IL)-7、IL-22、IL-10]与血清感染性指标[C-反应蛋白(CRP)、红细胞沉降率(ESR)、降钙素原(PCT)]水平;研究组患者根据病情严重程度分为轻症组和重症组,根据住院期间生存情况分为生存组与死亡组,分析Th17/Treg炎性细胞因子与感染性指标对病情严重程度的评估价值及对预后的预测价值。结果 研究组患者IL-7、IL-10、CRP、PCT水平高于对照组,重症组患者IL-7、IL-10、CRP、PCT水平高于轻症组(P<0.05),IL-7、PCT、CRP评估病情严重程度的曲线下面积(AUC)>0.75;死亡组患者IL-7、IL-10、CRP、PCT水平高于生存组(P<0.05);IL-7、IL-10预测患者生存情况的AUC>0.75。结论 AID合并肺部感染患者存在Th17/Treg炎性细胞因子与血清感染性指标水平异常的现象,且L-7、IL-10对AID合并重症肺部感染患者病情严重程度具有评估价值,对患者生存情况具有预测价值。
OBJECTIVE To explore the value of inflammatory cellular factors helper T17 cells/regulatory T cells(Th17/Treg) cells in evaluation of severity of autoimmune disease(AID) patients complicated with severe pulmonary infection. METHODS A total of 80 AID patients complicated with pulmonary infection who were treated in the General Hospital of The Yangtze River Shipping from Mar 2010 to Jul 2020 were assigned as the study group, meanwhile, 50 AID patients were chosen as the control group. The levels of Th17/Treg inflammatory cellular factors [interleukin(IL)-7, IL-22, IL-10] and serologic infection indexes [C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), procalcitonin(PCT)] were compared between the two groups of patients. The patients of the study group were divided into the mild group and the severe group according to the severity of disease and were divided into the survival group and the death group according to the status of survival during the hospital stay. The values of the Th17/Treg inflammatory secretion factors and infection indexes in evaluation of severity of disease and prediction of prognosis were observed. RESULTS The levels of IL-7, IL-10, CRP and PCT of the study group were significantly higher than those of the control group, the levels of IL-7, IL-10, CRP and PCT of the severe group were significantly higher than those of the mild group(P<0.05). The area under curve(AUC) of the IL-7, PCT and CRP was more than 0.75 in evaluation of severity of disease. The AUC of the IL-7 and IL-10 was more than 0.75 in prediction of survival status of the patients. CONCLUSION The AID patients complicated with pulmonary infection show abnormal levels of Th17 cell/Treg cell inflammatory cellular factors and serologic infection indexes. The IL-7 and IL-10 have value in evaluation of severity of the AID patients complicated with severe pulmonary infection and have value in prediction of survival status of the patients.
作者
王萍
林羽
李合
WANG Ping;LIN Yu;LI He(General Hospital of The Yangtze River Shipping,Wuhan,Hubei 430010,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2022年第6期866-870,共5页
Chinese Journal of Nosocomiology
基金
湖北省自然科学基金资助项目(20198953)。
