摘要
目的:运用Meta分析评价针灸治疗冠状动脉粥样硬化性心脏病(简称冠心病)心绞痛的临床疗效。方法:计算机检索中国生物医学文献数据库、中国知网、维普数据库、万方数据库、PubMed、Embase和The Cochrane Library等医学数据库,收集关于针灸治疗冠状动脉粥样硬化性心脏病心绞痛的临床随机对照试验(Randomized Controlled Trial,RCT)。应用“医学文献王”软件,由2名研究人员按照纳入和排除标准严格筛选文献。资料提取后,参照Cochrane协作网推荐的质量评价表对最终纳入文献进行质量评价。使用RevMan5.3软件进行Meta分析统计学处理,对针灸或针灸联合其他方法治疗冠状动脉粥样硬化性心脏病心绞痛的临床疗效进行比较。结果:一共检索到文献291篇,全部为中文文献,最终纳入符合要求的文献7篇,728例患者。按照随机分配方案产生、分配方案隐藏、盲法、数据结果完整性、选择性报告结果和其他影响真实性因素对最终纳入文献进行质量评价,7篇文献质量等级均为B。Meta分析结果显示:①临床疗效:[RR=1.25,95%CI(1.11-1.41),P<0.001]。②亚组分析:单独应用针灸临床疗效I2=89%[RR=1.30,95%CI(0.97-1.75),P=0.08];针灸联合药物治疗临床疗效I2=0%[RR=1.23,95%CI(1.14-1.33),P<0.00001]。③文献敏感性分析:删除兰奎玲的研究后I2=0%[RR=1.23,95%CI(1.08-1.39),P<0.00001]。结论:针灸或针灸联合药物治疗较单纯药物治疗冠状动脉粥样硬化性心脏病心绞痛具有明显的疗效优势(P<0.001),值得临床应用和推广。
Objective:To evaluate the clinical effect of acupuncture and moxibustion on angina pectoris of coronary heart disease by meta-analysis.Methods:The Chinese Biomedical Literature Database,CNKI,VIP database,Wanfang Database,PubMed,Embase and The Cochrane Library were searched by computer,and the clinical Randomized Controlled Trials(RCTS)on acupuncture in the treatment of angina pectoris of coronary heart disease were collected.The"Medical Literature King"software was used to strictly screen the literatures according to inclusion and exclusion criteria by 2 researchers.After data extraction,the quality of the included literatures was evaluated according to the quality evaluation form recommended by the Cochrane Collaboration.RevMan5.3 software was used for meta-analysis and statistical processing to compare the clinical efficacy of acupuncture or acupuncture combined with other methods in the treatment of angina pectoris of coronary heart disease.Results:A total of 291 literatures were retrieved,all of which were in Chinese.Finally,7 literatures meeting the requirements were included,including 728 patients.The qualities of the finally included literatures were evaluated according to random allocation scheme generation,allocation scheme hiding,blind method,data result integrity,selective report results and other factors affecting authenticity,all 7 literatures were rated B in quality.The results of meta-analysis showed:(1)Clinical efficacy:[RR=1.25,95%CI(1.11-1.41),P<0.001].(2)Subgroup analysis:I2=89%[RR=1.30,95%CI(0.97-1.75);Clinical efficacy:I2=0%[RR=1.23,95%CI(1.14-1.33),P<0.00001].(3)Literature sensitivity analysis:After deleting the study by LAN Kuiling,I2=0%[RR=1.23,95%CI(1.08-1.39),P<0.00001].Conclusion:Acupuncture and moxibustion or acupuncture combined with drug therapy has obvious therapeutic advantage compared with drug therapy alone(P<0.001),which is worthy of clinical application and promotion.
作者
肖梓潍
何娅娜
XIAO Ziwei;HE Ya'na
出处
《中医临床研究》
2022年第15期79-82,共4页
Clinical Journal Of Chinese Medicine
