摘要
目的分析靶向治疗与放化疗联合治疗肺癌脑转移患者对其神经功能、生活质量及不良事件的影响。方法选取2019年4月-2021年4月到邹城市人民医院诊治的88例肺癌脑转移患者的临床资料,按随机数表法分为两组。对照组44例给予放化疗,研究组44例给予靶向治疗与放化疗联合治疗。观察两组治疗效果、神经功能、不良事件情况。结果治疗后,研究组患者临床总有效率95.45%,比对照组81.82%高,差异有统计学意义(χ^(2)=4.062,P<0.05);两组治疗前神经功能比较,差异无统计学意义(t=0.562,P>0.05);治疗后,研究组患者神经功能评分(27.87±3.26)分比对照组(24.56±2.28)分高,差异有统计学意义(t=5.519,P<0.05);研究组治疗后生活质量评分(90.87±5.42)分高于对照组(81.34±5.02)分,差异有统计学意义(t=8.557,P<0.05);治疗后,研究组不良反应发生率4.55%比对照组20.45%低,差异有统计学意义(χ^(2)=5.091,P<0.05)。结论靶向治疗与放化疗联合治疗肺癌脑转移患者的临床疗效较好,可改善患者的神经功能,降低不良事件发生率,提升患者生活质量。
Objective To analyze the effect of targeted therapy combined with radiotherapy and chemotherapy on neu⁃rological function,quality life and adverse events in patients with brain metastases from lung cancer.Methods The clinical data of 88 patients with brain metastases from lung cancer who were diagnosed and treated in Zoucheng People's Hospital from April 2019 to April 2021 were selected and divided into two groups according to the random number table.44 patients in the control group were treated with radiotherapy and chemotherapy,and 44 patients in the study group were treated with targeted therapy combined with radiotherapy and chemotherapy.The therapeutic ef⁃fect,neurological function and adverse events of the two groups were observed.Results After treatment,the total clinical effective rate in the study group was 95.45%higher than that in the control group 81.82%,and the difference was statistically significant(χ^(2)=4.062,P<0.05).There was no statistically significant difference in neurological func⁃tion between the two groups before treatment(t=0.562,P>0.05).After treatment,the neurological function score of the study group(27.87±3.26)points was higher than that of the control group(24.56±2.28)points,and the difference was statistically significant(t=5.519,P<0.05).The quality of life score of the study group(90.87±5.42)points was higher than that of the control group(81.34±5.02)points,and the difference was statistically significant(t=8.557,P<0.05).After treatment,the incidence of adverse reactions in the study group was 4.55%lower than 20.45%in the control group,and the difference was statistically significant(χ^(2)=5.091,P<0.05).Conclusion Targeted therapy com⁃bined with radiotherapy and chemotherapy has good clinical efficacy in the treatment of lung cancer patients with brain metastases,which can improve the neurological function of patients,reduce the incidence of adverse events,and improve the quality of life of patients.
作者
宋伟
SONG Wei(Department of Thoracic Surgery,Zoucheng People's Hospital,Jining,Shandong Province,273500 China)
出处
《系统医学》
2022年第12期127-130,共4页
Systems Medicine
关键词
靶向治疗
放化疗
肺癌脑转移
神经功能
不良事件
Targeted therapy
Radiotherapy and chemotherapy
Brain metastases from lung cancer
Neurological function
Adverse events
