摘要
目的:分析质子泵抑制剂(PPI)预防外科手术患者围手术期应激性溃疡(SU)的应用情况。方法:选取博白县人民医院2021年1-6月收治的外科手术患者529例。根据是否具有SU高危因素,将其分为高危因素组(n=237)和非高危因素组(n=292)。所有患者均预防性使用PPI,主要包括奥美拉唑、雷贝拉唑、泮托拉唑、兰索拉唑。分析所有患者PPI使用情况,不同手术患者PPI使用疗程及住院时间,PPI用药不合理现象。比较两组住院情况。结果:奥美拉唑、泮托拉唑剂量以≥40 mg为主,雷贝拉唑、兰索拉唑剂量以<40 mg为主。在外科手术患者中,使用PPI胃、肠手术患者较多,且胃、肠手术患者PPI疗程、住院时间长于其他手术患者。高危因素组的PPI费用、药物总费用、住院费用均显著高于非高危因素组,PPI/药物总费用、PPI/住院总费用均显著低于非高危因素组(P<0.05)。PPI使用存在用药不合理现象,主要为无指征用药、剂量不合理、给药途径不合理、用药疗程过长。结论:在外科手术患者围手术期PPI的预防使用中,存在用药不合理现象,需要强化对PPI用药的管理,提升PPI的用药合理性。
Objective:To analyze the application condition of proton pump inhibitor(PPI)in preventing perioperative stress ulcer(SU)in surgical patients.Method:A total of 529 surgical patients admitted to Bobai County People’s Hospital from January to June 2021 were selected.According to whether there were SU high-risk factors,they were divided into high-risk factor group(n=237)and non high-risk factor group(n=292).All patients used PPI prophylactically,mainly including Omeprazole,Rabeprazole,Pantoprazole and Lansoprazole.The use of PPI in all patients,the course of PPI use and hospital stay in different surgical patients,and irrational phenomena in the use of PPI were analyzed.The hospitalizations condition of the two groups were compared.Result:The dosage of Omeprazole and Pantoprazole was≥40 mg,and the dosage of Rabeprazole and Lansoprazole was<40 mg.Among the surgical patients,PPI was used more for gastric and intestinal surgery patients,and the course of PPI and hospital stay of gastric and intestinal surgery patients were longer than those of other surgery patients.The PPI cost,total drug cost and hospitalization cost of the high-risk factor group were significantly higher than those of the non high-risk factor group,and the PPI/total drug cost and PPI/total hospitalization cost were significantly lower than those of the non high-risk factor group(P<0.05).There were irrational phenomena in the use of PPI,mainly including no indication of drug use,unreasonable dose,unreasonable route of give drug and long course of medication.Conclusion:In the prophylactic use of PPI in perioperative period for surgical patients,there is an irrational phenomenon in the use of drug.It is necessary to strengthen the management of PPI medication and improve the rationality of PPI medication.
作者
庞玉娜
PANG Yuna(Bobai County People’s Hospital,Bobai 537600,China)
出处
《中外医学研究》
2022年第17期124-127,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
