摘要
目的:通过干预分析我院外科住院手术患者中质子泵抑制剂在预防应激性溃疡方面的使用情况,为临床合理使用质子泵抑制剂提供参考。方法:基于我院PASS系统,提取2018年1–6月(干预前)与2018年7–12月(干预后)我院10个外科临床科室使用质子泵抑制剂的病历,共计2633例。从预防应激性溃疡的角度,对其适应证、用药品种、用法用量、用药时间、相互作用方面进行回顾性评价分析。结果:质子泵抑制剂的使用在干预前后存在统计学差异(P<0.05),其中干预前预防性使用1651例,干预后预防性使用982例,质子泵抑制剂在临床不合理使用主要包括无适应证用药、用药时机及疗程不合理、用法用量不适宜、溶媒选择不合理以及药物相互作用。结论:干预后质子泵抑制剂的预防性使用仍存在不合理现象,药师与临床科室应积极沟通,确保质子泵抑制剂在预防应激性溃疡中的应用更加安全、合理、有效。
Objective:To observe the effect of pharmaceutical intervention on preventive use of proton pump inhibitor(PPI)for stress ulcer(SU)in patients undergoing operations in the surgical department of our hospital in order to provide references for clinical rational use of PPI.Methods:Data of 2633 cases using PPI in ten surgical departments from pre-intervention(from January to June in 2018)and post-intervention(from July to December in 2018)were extracted through the prescription automatic screening system(PASS)in our hospital.Application data of PPI for SU were retrospectively analyzed in terms of the indication,drug varieties,usage and dosage,duration,drug interaction.Results:There were 1651 cases that used PPIs preventively for SU before intervention,while there were 982 cases after intervention,which were significantly different(P<0.05).Irrational use of PPI was mainly represented as having no indication,improper administration time,improper duration,improper usage,improper dose,improper medium and having improper drug interaction.Conclusion:There was still irrational use of PPI for SU after pharmaceutical intervention.It is necessary for physicians and pharmacists to have good communication in order to ensure the more safe,reasonable and effective use of PPI for SU.
作者
陈婧
王明
尹东锋
CHEN Jing;WANG Ming;YIN Dong-feng(Department of Clinical Pharmacology,General Hospital of Xinjiang Military Region,Urumqi 830000,China)
出处
《中国药物应用与监测》
CAS
2019年第6期365-368,共4页
Chinese Journal of Drug Application and Monitoring
基金
全军医学科技青年培育计划拔尖项目(16QNP012)
关键词
质子泵抑制剂
预防用药
应激性溃疡
合理用药
Proton pump inhibitor
Preventive medicine
Stress ulcer
Rational drug use
