摘要
目的探讨在动脉粥样硬化诊断过程中脂蛋白相关磷脂酶A2(Lp-PLA2)水平和血清超氧化物歧化酶(SOD)联合检测的临床意义。方法选择2020年1—12月本院心脑血管科室就诊的125例动脉粥样硬化(AS)患者作为AS(125例)组和选择本院同期健康体检中心体检者50名作为对照组(50例)。采用邻苯三酚自氧化法和散射比浊法分别对两组的血清SOD及Lp-PLA2等指标进行检测,探讨血清SOD及Lp-PLA2在动脉粥样硬化患者诊断及预测中的作用。结果AS组患者的血清Lp-PLA2、TC、TG、GLU含量水平均显著高于对照组,差异有统计学意义(P<0.05);AS组患者的SOD血清含量水平显著低于对照组,差异有统计学意义(P<0.05);经类logistic逐步回归分析,SOD及Lp-PLA2是动脉粥样硬化的影响因素(P<0.05);采用ROC曲线分析,得到SOD及Lp-PLA2曲线下面积分别为0.813、0.726,而两者联合检测曲线下面积为0.891,说明两者联合检测的诊断效能更高。结论SOD及Lp-PLA2是动脉粥样硬化的影响因素,在临床工作中SOD及Lp-PLA2水平及其联合检测对于预测动脉粥样硬化的发生及临床诊断具有重要价值。
Objective To explore the significance of detecting serum superoxide dismutase(SOD)and lipoprotein-related phospholipase A2(Lp-PLA2)levels in the diagnosis of atherosclerosis.Methods From January to December in 2020,125 patients suffer with atherosclerosis(AS)those were admitted to cardio cerebrovascular department were selected as the experimental group,and 50 patients in health examination center were selected as the experimental group.The indexes of serum SOD and Lp-PLA2 were detected by pyrogallol autooxidation method and scattering turbidimetry,respectively,to explore the role of serum SOD and Lp-PLA2 in the diagnosis and prediction for patients suffered with atherosclerosis.Results The serum Lp-PLA2,TC,TG,and GLU content of atherosclerosis patients were significantly higher than those of health control group,differences were statistically significant(P<0.05).The serum SOD content of experimental group was significantly lower than that of control group,with statistical significance(P<0.05).Logistic stepwise regression analysis showed that SOD and Lp-PLA2 are the influencing factors of atherosclerosis(P<0.05).ROC curve analysis showed that the area under the curve of SOD and Lp-PLA2 were 0.813 and 0.726,respectively,and the area under the curve of the combined detection of SOD and Lp-PLA2 was 0.891,indicating that the combined detection of SOD and Lp-PLA2 had higher diagnostic efficiency.Conclusions SOD and Lp-PLA2 are the influencing factors of atherosclerosis.The levels of SOD and Lp-PLA2 and their combined detection in clinical work are of great value in predicting the occurrence and clinical diagnosis of atherosclerosis.
作者
江明菲
周容
查茜
浦春
路勇
Jiang Mingfei;Zhou Rong;Zha Qian;Pu Chun;Lu Yong(School of clinical medicine,Wannan medical College,Wuhu,Anhui,241002,China;Department of clinical laboratory,the first affiliated hospital of Wannan Medical College,Wuhu,Anhui,241002,China)
出处
《齐齐哈尔医学院学报》
2022年第6期515-518,共4页
Journal of Qiqihar Medical University
基金
国家级大学生创新创业训练计划(201910368057)
安徽省高校优秀拔尖人才培育项目(gxyq2020026)。
