摘要
本文通过非共价作用,合成四氨基酞菁铟功能化石墨烯(rGO-InTAPc)纳米材料,并用于构筑高灵敏的黄芩苷电化学传感器。由于rGO-InTAPc较大的比表面积和优异的电子传输能力,显著提高了黄芩苷的电化学响应。采用循环伏安法、计时电量法及差分脉冲伏安法详细地研究了黄芩苷在该传感器上的电化学行为。在最佳条件下,响应峰电流与黄芩苷在0.005~10μmol/L的浓度范围内呈良好的线性关系,检出限(S/N=3)低至0.5 nmol/L。将该方法应用于中药制剂银黄颗粒中黄芩苷含量的分析,与高效液相色谱结果具有高度的一致性。
In this paper, graphene nanocomposites functionalized with soluble indium tetraaminophthalocyanine organic dyes(rGO-InTAPc) were synthesized by non-covalent functionalization and used to construct a highly sensitive baicalin electrochemical sensor.Due to the large specific surface area and excellent electron transport capacity of rGO-InTAPc, the electrochemical response of baicalin was significantly improved.The electrochemical behavior of baicalin on the sensor was studied in detail by cyclic voltammetry, chronoamperometry and differential pulse method.Under the optimum conditions, the sensor showed a good linear relationship between response peak current and baicalin concentration in the range of 0.005-10 μmol/L with the detection limit of 0.5 nmol/L(S/N=3).The method was applied to the analysis of baicalin in a traditional Chinese medicine preparation of Yinhuang granules.The results were satisfactory and highly consistent with those of HPLC.
作者
王琪铭
史艳梅
魏森
吴明侠
苗明三
李秀敏
WANG Qiming;SHI Yanmei;WEI Sen;WU Mingxia;MIAO mingsan;LI Xiumin(Henan University of Chinese Medicine,Zhengzhou 450001;New York Medical College,New York,NY 10595,USA)
出处
《分析科学学报》
CAS
CSCD
北大核心
2022年第3期327-332,共6页
Journal of Analytical Science
基金
河南省科技攻关项目(No.212102311037)
河南中医药大学项目(No.03301232,00104358)。
关键词
四氨基酞菁铟
石墨烯
电化学传感器
黄芩苷
Indium tetraaminophthalocyanine
Graphene
Electrochemical sensor
Baicalin
