摘要
目的:观察百令胶囊联合前列地尔对糖尿病肾病(diabetic nephropathy,DN)患者炎症因子及肝肾功能的影响。方法:选择102例DN患者,应用随机数字表法分为观察组和对照组,每组51例。对照组接受前列地尔治疗;观察组接受百令胶囊联合前列地尔治疗。疗程4个月。观察两组临床疗效,炎症因子指标[白介素6(interleukin 6,IL-6)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)],肝肾功能指标[血肌酐(serum creatinine,Scr)、尿素氮(blood urea nitrogen,BUN)、β_(2)-微球蛋白(β_(2)-microglobulin,β_(2)-MG)],肾脏纤维化指标[Ⅳ型胶原(collagenⅣ,CⅣ)、血浆层黏蛋白(laminin,LN)、Ⅲ型前胶原(procollagenⅢ,PCⅢ)]及血糖指标[(fasting plasma glucose,FPG)、糖化血红蛋白(HemoglobinA1c,HbA1c)、餐后2小时血糖(2-hour postprandial blood glucose,2hPG)]变化情况。结果:观察组总有效率[90.20%(46/51)]高于对照组[74.51%(38/51)](P<0.05)。治疗后,两组IL-6、TNF-α、Scr、β_(2)-MG、UAER、CⅣ、LN、PCⅢ、FPG、HbA1c、2hPG水平均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。结论:DN患者接受百令胶囊联合前列地尔治疗可行性较高,可降低患者炎症因子水平,改善肾功能,抑制肾脏纤维化进程。
Objective:To observe the effects of Bailing capsules and alprostadil on inflammatory factors,liver and renal function in patients with DN.Methods:A total of 102 DN patients were selected,divided into the observation group and the control group,with 51 cases in each group,according to random number table method.The control group was treated by alprostadil,and the observation group by Bailing capsules and alprostadil.the course was four months.To observe clinical effects,the indexes of inflammatory factor[IL-6,TNF-α],the indicators of liver and renal function[Scr,BUN and β_(2)-MG],the indexes of renal fibrosis[CⅣ,LN and PCⅢ]and the indexes of blood glucose[FPG,HbA1c,2hPG]between both groups.Results:Total effective rare of the observation group was[90.20%(46/51)],higher than[74.51%(38/51)]of the control group(P<0.05).After treatment,the levels of IL-6,TNF-α,Scr,β2-MG,UAER,CⅣ,LN,PCⅢ,FPG,HbA1c and 2hPG lowered in both groups compared with these before treating(P<0.05),and the observation group was lower than the control group(P<0.05).Conclusion:It is feasible for DN patients to take Bailing capsules and alprostadil which could lower the levels of inflammatory factors,improve renal function and inhibit the progression of renal fibrosis.
作者
王永军
张云
石良静
吕培
宫磊
左志瑶
刘建震
WANG Yongjun;ZHANG Yun;SHI Liangjing;LYU Pei;GONG Lei;ZUO Zhiyao;LIU Jianzhen(Hebei Chest Hospital,Shijiazhuang 050041,China;Nanhe County People′s Hospital)
出处
《西部中医药》
2022年第6期115-117,共3页
Western Journal of Traditional Chinese Medicine
基金
河北省2018年度医学科学研究重点课题(20180677)。
关键词
糖尿病肾病
百令胶囊
前列地尔
炎症因子
肝肾功能
diabetic nephropathy
Bailing capsules
alprostadil
inflammatory factors
liver and renal function
