摘要
目的探究精神分裂症住院患者睡眠质量现况及相关因素。方法纳入2019年8月至2021年3月在北京大学第六医院、驻马店市第二人民医院以及聊城市第四人民医院等7家医院住院的精神分裂症患者269例,进行简明精神病量表(BPRS)、匹兹堡睡眠质量指数(PSQI)、9条目患者健康问卷(PHQ-9)、广泛性焦虑障碍量表(GAD-7)及简明国际神经精神访谈自杀风险模块等评估。基于PSQI总分>5分为低睡眠质量的评定标准,将患者分为低睡眠质量组和正常睡眠质量组,比较两组一般人口学资料及临床特征,并采用Spearman相关和多因素logistic回归进行睡眠质量的相关因素分析。结果精神分裂症住院患者低睡眠质量的发生率约为44.6%(120/269)。相比于正常睡眠质量组,低睡眠质量患者中有饮酒史、服用苯二氮䓬类药物(BZDs)和当前自杀风险的比例更高,BPRS总分及因子分(思维障碍、焦虑抑郁、敌对猜疑和激活性)、PHQ-9和GAD-7得分更高(均P<0.05)。Spearman相关分析发现,PSQI总分与BPRS总分(r=0.323)、PHQ-9得分(r=0.553)、GAD-7得分(r=0.456)及当前自杀风险等级(r=0.320)显著正相关(均P<0.001)。多因素logistic回归结果显示,有饮酒史(OR=2.897,95%CI:1.002~8.372)、服用BZDs(OR=3.181,95%CI:1.548~6.534)、思维障碍(OR=1.563,95%CI:1.015~2.406)、共患抑郁(OR=4.968,95%CI:1.869~13.202)及当前自杀风险(OR=2.496,95%CI:1.360~4.581)与低睡眠质量独立相关(均P<0.05)。结论精神分裂症住院患者低睡眠质量常见,有饮酒史、服用BZDs、思维障碍、共患抑郁和当前自杀风险是低睡眠质量的独立相关因素。
Objective To explore the status and correlates of sleep quality in hospitalized patients with schizophrenia.Methods A total number of 269 schizophrenia inpatients were recruited from 7 hospitals including Peking University Sixth Hospital,Zhumadian Second People′s Hospital and Liaocheng Fourth People′s Hospital from August 2019 to March 2021.The Brief Psychiatric Rating Scale(BPRS),the Pittsburgh Sleep Quality Index(PSQI),the 9-item Patient Health Questionnaire(PHQ-9),the 7-item Generalized Anxiety Disorder Scale(GAD-7)and the suicide module of Mini-International Neuropsychiatric Interview were evaluated.Poor sleep quality was determined by the score of more than 5 according to PSQI,all patients were divided into groups of poor and normal sleep quality.The general demographic data and clinical characteristics of two groups were compared,and the correlates of sleep quality were obtained by Spearman correlations and multiple logistic regression.Results The prevalence of poor sleep quality in schizophrenia inpatients was up to 44.6%(120/269).Compared with normal sleep quality group,inpatients with poor sleep quality had higher rates of alcohol consumption history,use of benzodiazepines(BZDs)and current suicide risk,and BPRS total score,factor scores(thinking disorders,anxious-depression,hostile-suspiciousness and activation),PHQ-9 and GAD-7 scores were also higher(all P<0.05).Spearman correlation analyses showed that PSQI total score were significantly positively correlated with BPRS total score(r=0.323),PHQ-9 score(r=0.553),GAD-7 score(r=0.456)and current suicide risk level(r=0.320)(all P<0.001).Multiple logistic regression showed that history of alcohol consumption(OR=2.897,95%CI:1.002-8.372),use of BZDs(OR=3.181,95%CI:1.548-6.534),thinking disorders(OR=1.563,95%CI:1.015-2.406),comorbidity with depression(OR=4.968,95%CI:1.869-13.202),and current suicide risk(OR=2.496,95%CI:1.360-4.581)were independently correlated with poor sleep quality(all P<0.05).Conclusion Poor sleep quality is common in hospitalized patients with schizophrenia,and history of alcohol consumption,use of BZDs,thinking disorders,comorbidity with depression and current suicide risk are independent correlates of poor sleep quality.
作者
陈云
张绿凤
张洪乐
汪迪
张秋伏
陈娆
褚鸷
胡思帆
孙洪强
Chen Yun;Zhang Lüfeng;Zhang Hongle;Wang Di;Zhang Qiufu;Chen Rao;Chu Zhi;Hu Sifan;Sun Hongqiang(Peking University Sixth Hospital,NHC Key Laboratory of Mental Health,National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100191,China;Zhumadian Second People′s Hospital,Zhumadian 463000,China;Liaocheng Fourth People′s Hospital,Liaocheng 252000,China;Beijing Changping Hospital of Integrated Chinese and Western Medicine,Beijing 102208,China;Beijing Tongzhou Psychiatric Hospital,Beijing 101101,China;Beijing Chaoyang Third Hospital,Beijing 100121,China;Beijing Xicheng District Ping′an Hospital,Beijing 100035,China)
出处
《中华健康管理学杂志》
CAS
CSCD
2022年第5期318-324,共7页
Chinese Journal of Health Management
基金
国家自然科学基金(81771429)。
关键词
精神分裂症
睡眠质量
精神症状
自杀
Schizophrenia
Sleep quality
Psychiatric symptom
Suicide
