摘要
目的:分析高龄孕妇再生育出生缺陷情况及其影响因素。方法:回顾性分析佛山市高明区人民医院2019年1月-2021年1月接收的100例高龄孕妇的临床资料。根据其再生育有无发生出生缺陷将其分为甲组(出生缺陷)和乙组(非出生缺陷)。统计甲组再生育出生缺陷发生情况,采集两组相关临床资料。对高龄孕妇再生育出生缺陷发生进行单因素和多因素分析。结果:甲组出生缺陷中以心脏系统畸形构成比最高,为47.37%,其次分别为中枢神经系统畸形和泌尿生殖系统畸形,构成比分别为21.05%和15.79%,肌肉骨骼系统畸形、胃肠系统畸形、眼部及耳部畸形构成比均为5.26%。在心脏系统畸形类型中,以室间隔缺损构成比最高,为33.33%,其次为法洛氏四联症和房室间隔缺损,构成比均为22.22%,完全型大动脉转位和房间隔缺损构成比均为11.11%。甲组孕期贫血发生率明显高于乙组,补充叶酸及钙铁微量元素发生率明显低于乙组,饲养动物、吸烟、饮酒发生率均明显高于乙组(P<0.05)。多因素Logistic回归分析结果显示孕期贫血、未补充叶酸及钙铁微量元素、有饲养动物、吸烟及饮酒均是再生育出生缺陷发生的独立危险因素(P<0.05)。结论:二孩政策后,高龄孕妇再生育出生缺陷发生风险较高,出生缺陷多以先天性心脏病较为多见,孕期贫血、未补充叶酸及钙铁微量元素、有饲养动物、吸烟及饮酒均是再生育出生缺陷发生的独立危险因素,临床需要提高重视及时采取干预措施,以尽量减少高龄孕妇再生育出生缺陷的发生。
Objective:To analyze the status of the reproduction birth defects in elderly pregnant women and its influencing factors.Method:The clinical data of 100 elderly pregnant women admitted to People’s Hospital of Gaoming District of Foshan from January 2019 to January 2021 were retrospectively analyzed.They were divided into group A(birth defects)and group B(non-birth defects)according to whether they had birth defects or not.The occurence situation of reproductive birth defects in group A was analyzed,and the clinical data of the two groups were collected.Univariate and multivariate analysis were carried out on the occurrence of reproductive birth defects in elderly pregnant women.Result:Among the birth defects in group A,the composition ratio of cardiac system malformation was the highest,which was 47.37%,followed by central nervous system malformation and urogenital system malformation,the composition ratios were 21.05%and 15.79%respectively,and the composition ratio of musculoskeletal system malformation,gastrointestinal system malformation,eye and ear malformation was 5.26%.Among the types of cardiac system malformations,ventricular septal defect has the highest composition ratio,which was 33.33%,followed by tetralogy of Fallot and atrioventricular septal defect,the composition ratio was 22.22%,the composition ratio of complete transposition of great arteries and atrial septal defect was 11.11%.The incidence of anemia during pregnancy in group A was significantly higher than that in group B,the incidence of folic acid supplementation and calcium and iron trace elements was significantly lower than that in group B,and the incidences of feeding animals,smoking and drinking were significantly higher than those in group B(P<0.05).Multivariate Logistic regression analysis showed that anemia during pregnancy,non supplement folic acid and trace elements of calcium and iron,animal feeding,smoking and drinking were independent risk factors for the occurrence of reproductive birth defects(P<0.05).Conclusion:After the two-child policy,elderly pregnant women have a higher risk of reproductive birth defects.Birth defects are more common in congenital heart disease.Anemia during pregnancy,non supplement folic acid and trace elements of calcium and iron,animal feeding,smoking and drinking were independent risk factors for the occurrence of reproductive birth defects.Clinical need to pay more attention to timely take the intervention measures to minimize the occurence of reproductive birth defects in elderly pregnant women.
作者
张考珍
严燕艺
商明
关换琼
张爱珍
ZHANG Kaozhen;YAN Yanyi;SHANG Ming;GUAN Huanqiong;ZHANG Aizhen(People’s Hospital of Gaoming District of Foshan,Foshan 528500,China;不详)
出处
《中外医学研究》
2022年第10期139-142,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
二孩政策
高龄孕妇
再生育出生缺陷
影响因素
Two-child policy
Eldehy pregnant women
Rebirth birth defects
Influencing factors
