摘要
目的探讨垂体后叶素联合卡前列素氨丁三醇和缩宫素改善产后出血产妇凝血功能的效果。方法选取巩义市妇幼保健院2018年4月至2020年4月住院分娩产妇86例,按随机投掷法分为参照组和研究组。参照组用常规治疗方案即卡前列素氨丁三醇、缩宫素联合,研究组同时辅以垂体后叶素。对比两组产妇产后30 min、产后2 h及产后24 h出血量,同时对比两组治疗前后部分活化凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)等凝血功能指标水平,记录两种药物方案患者第三产程、止血、住院时间及不良反应事件例数。结果研究组产后30 min、产后2 h及产后24 h出血量均少于参照组,差异有统计学意义(P<0.05);两组产妇治疗前APTT、TT、FIB等凝血功能指标水平差异无统计学意义(P>0.05);治疗后研究组APTT、TT、FIB各指标水平均低于参照组,差异有统计学意义(P<0.05)。研究组第三产程时间、止血时间、住院时间均短于参照组,差异有统计学意义(P<0.05)。研究组不良事件发生率低于参照组,差异有统计学意义(P<0.05)。结论对分娩产妇产前采取有效措施,用垂体后叶素、卡前列素氨丁三醇、缩宫素联合干预,可改善机体凝血功能,预防或者减少产后出血,效果显著,能够有效缩短产妇产程以及住院时间,降低不良事件发生风险,可临床应用。
Objective To investigate the effect of pituitary hormone combined with carboprost tromethamine and oxytocin in improving blood coagulation function in puerperae with postpartum hemorrhage.Methods A total of 86 puerperae in our hospital from April 2018 to April 2020 were selected and divided into the reference group and the study group according to the random throwing method.The reference group was treated with conventional therapy,namely carboprost tromethamine combined with oxytocin,and the study group was supplemented with vasopressin.The blood loss at 30 minutes,2 hours and 24 hours after delivery was compared between the two groups,and the levels of coagulation function indexes such as partially activated thromboplastin time(APTT),thrombin time(TT),and fibrinogen(FIB)were compared between the two groups before and after treatment,the third stage of labor,hemostasis,hospital stay and the number of adverse events were recorded in patients with the two drug regimens.Results The bleeding volume in the study group at 30 minutes,2 hours and 24 hours after delivery was less than that of the reference group,with statistical significance(P<0.05).After treatment,the levels of APTT,TT,and FIB in the study group were lower than those in the reference group(P<0.05).The third stage of labor time,hemostasis time,and hospital stay in the study group were shorter than those in the reference group(P<0.05).The incidence of adverse events in the study group was lower than that in the reference group,and the difference was statistically significant(P<0.05).Conclusion Taking effective measures before delivery for puerperae,combined intervention with pituitary hormone,carboprost tromethamine and oxytocin can improve the body’s blood coagulation function,prevent or reduce postpartum hemorrhage,and the effect is remarkable,which can effectively shorten the duration of labor and hospitalization time,and reduce the risk of adverse events,and can be promoted clinically.
作者
张高锦
姚明莉
ZHANG Gaojin;YAO Mingli(Gongyi Maternal and Child Health Hospital,Gongyi Henan 451200,China)
出处
《临床研究》
2022年第3期84-87,共4页
Clinical Research
关键词
垂体后叶素
卡前列素氨丁三醇
缩宫素
产后出血
凝血功能
pituitrin
carprost tromethamine
oxytocin
postpartum hemorrhage
blood coagulation function
