摘要
Summary What is already known on this topic?The prevalence of structural birth defects,especially neural tube defects,decreased after national folic acid(FA)supplementation initiation.What is added by this report?The prevalence of orofacial clefts(OFCs)in five counties of Shanxi Province in northern China,including most subtypes except cleft palate,showed a downward trend in the past two decades.In this study,pre-perinatal prevalence increased due to earlier detection.
基金
This study is supported by the National Key Research and Development Program,Ministry of Science and Technology from P.R.China(Grant No.2016YFC1000501)
Natural Science Foundation of China(No.81973056)
Medical Research Council(Grant Ref:MR/T003847/1)from UK.
