摘要
目的观察血浆微纤丝关联蛋白5(microfibrillar associated protein 5,MFAP5)水平在多囊卵巢综合征(PCOS)患者血浆中的水平,探讨其与糖脂代谢及性激素的关系。方法选取50例PCOS患者和同期体检的65名女性健康体检者分别作为PCOS组和对照组,比较2组间临床资料及血浆MFAP5水平的差异。结果PCOS组血浆MFAP5水平明显高于对照组(P<0.01),PCOS超重亚组血浆MFAP5水平高于对照组超重亚组(P<0.01),而2组未超重亚组间血浆MFAP5水平差异无统计学意义(P>0.05)。相关性分析显示,血浆MFAP5水平与腰围、低密度脂蛋白胆固醇、空腹胰岛素、稳态模型评估的胰岛素抵抗指数(HOMA-IR)、HbA1C、睾酮、LH/FSH比值、白细胞呈正相关(P<0.05或P<0.01);与体重、体重指数(BMI)、臀围、腰臀比、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、总胆固醇(TC)、血糖无显著相关性(P>0.05)。在PCOS组中,血浆MFAP5水平与体重、BMI、腰围、臀围、TC、白细胞呈正相关(P<0.05或P<0.01);与腰臀比、HDL-C、TG、血糖、空腹胰岛素、HOMA-IR、白细胞、性激素无显著相关性(P>0.05)。多因素logistic回归分析显示,MFAP5是PCOS发生的独立危险因素(P<0.05)。结论MFAP5在PCOS患者血浆中水平升高,并与BMI、腰围、臀围、TC密切相关。血浆MFAP5是PCOS的独立危险因素,可能参与PCOS疾病的发生发展过程。
Objective To assess plasma microfibrillar associated protein 5(MFAP5)level in patients with polycystic ovary syndrome(PCOS),and to explore its relationship with glucose and lipid metabolism as well as sex hormones.Methods Fifty PCOS patients and 65 healthy female subjects were selected as PCOS group and control group,respectively.Clinical data and plasma MFAP5 levels between the two groups were compared.Results The plasma MFAP5 level in PCOS group was significantly higher than that in control group(P<0.01),and the plasma MFAP5 level in PCOS overweight subgroup was higher than that in control subgroup(P<0.01).No difference was observed in plasma MFAP5 level between the two non-overweight subgroups(P>0.05).Correlation analysis showed that plasma MFAP5 level was positively correlated with waist circumference,low density lipoprotein-cholesterol,fasting insulin,homoeostasis model assessment of insulin resistance index(HOMA-IR),HbA1C,testosterone,LH/FSH ratio,and leukocyte(P<0.05 or P<0.01).There was no significant correlation of MFAP5 with body weight,body mass index(BMI),hip circumference,waist hip ratio,high density lipoprotein-cholesterol(HDL-C),triglyceride,total cholesterol,and blood glucose(P>0.05).In PCOS group,plasma MFAP5 level was positively correlated with body weight,BMI,waist circumference,hip circumference,total cholesterol,and leukocyte(P<0.05 or P<0.01).There was no significant correlation of MFAP5 with waist hip ratio,HDL-C,triglyceride,blood glucose,fasting insulin,HOMA-IR,leukocyte,and sex hormones(P>0.05).Multivariate logistic regression analysis showed that MFAP5 was an independent risk factor for PCOS(P<0.05).Conclusion Plasma MFAP5 level is increased in PCOS patients and is closely related to BMI,waist circumference,hip circumference,and total cholesterol.Plasma MFAP5 is an independent risk factor for PCOS,which may be involved in the pathogenesis of PCOS.
作者
廖明钰
李行
赵欢
李蔚鑫
石榴
王秀丽
郑宏庭
隆敏
Liao Mingyu;Li Xing;Zhao Huan;Li Weixin;Shi Liu;Wang Xiuli;Zheng Hongting;Long Min(Department of Endocrinology,the Second Affiliated Hospital of Army Military Medical University,Chongqing 400037,China;Department of Endocrinology,Medical School of Nanjing University,Jinling Hospital,Nanjing 210016,China;Health Management Department,the Second Affiliated Hospital of Army Military Medical Unirersity,Chongqing 400037,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2022年第1期30-35,共6页
Chinese Journal of Endocrinology and Metabolism
基金
重庆市杰出青年科学基金项目(cstc2020jcyj-jqX0017)
新桥医院"临床医学科研人才"项目(2019XLC3021)。
关键词
多囊卵巢综合征
微纤丝关联蛋白5
糖脂代谢
胰岛素抵抗
Polycystic ovary syndrome
Microfibrillar associated protein 5
Glycolipid metabolism
Insulin resistance
