摘要
目的探讨血清P-选择素糖蛋白配体1(PSGL-1)、膜联蛋白A1(ANXA1)、降钙素原(PCT)对慢性阻塞性肺疾病(COPD)急性发作并发肺部感染的诊断价值。方法选取2018年9月至2021年8月河南省人民医院收治的102例COPD急性发作患者为研究组,并以同期30例健康查体者为对照组。入院后研究组患者均进行胸部CT扫描确定肺部感染情况,并同期进行血清PSGL-1、ANXA1、PCT水平、临床肺部感染评分(CPIS)的检测。对照组亦进行血清PSGL-1、ANXA1、PCT水平的检测。分析研究组血清PSGL-1、ANXA1、PCT水平与COPD急性发作并发肺部感染及CPIS的关系,并分析研究组血清PSGL-1、ANXA1、PCT水平对COPD急性发作并发肺部感染的诊断价值。结果研究组血清PSGL-1、ANXA1、PCT水平均较对照组高,差异有统计学意义(P<0.05)。研究组肺部感染发生率为28.43%(29/102)。与无肺部感染患者比较,发生肺部感染患者的血清PSGL-1、ANXA1、PCT水平、CPIS均较高,差异有统计学意义(P<0.05)。Logistic多元回归分析结果显示,血清PSGL-1、ANXA1、PCT水平均为COPD急性发作患者并发肺部感染的危险因素(P<0.05)。Pearson线性相关分析结果显示,研究组血清PSGL-1、ANXA1、PCT水平与CPIS均呈正相关(P<0.05)。ROC曲线分析结果显示,血清PSGL-1、ANXA1、PCT水平单独和联合诊断急性发作并发肺部感染的准确性均较高,其中以血清PSGL-1、ANXA1、PCT水平联合诊断急性发作并发肺部感染的敏感度、特异度以及准确性最高(P<0.05)。结论COPD急性发作患者的血清PSGL-1、ANXA1、PCT水平较高且与肺部感染发生及其严重程度均相关,血清PSGL-1、ANXA1、PCT水平联合检测可用于COPD急性发作并发肺部感染的诊断。
Objective To explore the diagnostic value of serum P-selectin glycoprotein ligand 1(PSGL-1),annexin A1(ANXA1)and procalcitonin(PCT)in the diagnosis of acute COPD with pulmonary infection.Methods A total of 102 patients with acute exacerbation of COPD who were admitted from September 2018 to August 2021 were selected as the study group,and 30 healthy patients had physical checkups during the same period were selected as the control group.After admission,all patients in the study group underwent chest CT scans to determine their lung infections.At the same time,in the study group,serum PSGL-1,ANXA1,PCT levels,and clinical lung infection score(CPIS)were tested.The control group was also tested for serum PSGL-1,ANXA1,and PCT levels.The relationship between serum PSGL-1,ANXA1,PCT levels in the study group with acute COPD with pulmonary infection and CPIS were analyzed,and the value of serum PSGL-1,ANXA1,PCT levels in the diagnosis of acute COPD with pulmonary infection was analyzed.Results The levels of serum PSGL-1,ANXA1 and PCT in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).The incidence of pulmonary infection in the study group was 28.43%(29/102).Compared with patients without pulmonary infection,the levels of serum PSGL-1,ANXA1,PCT and CPIS in patients with pulmonary infection were higher,and the difference was statistically significant(P<0.05).Logistic multiple regression analysis showed that serum PSGL-1,ANXA1,and PCT levels were all risk factors for acute COPD with pulmonary infection(P<0.05).The results of Pearson linear correlation analysis showed that the serum PSGL-1,ANXA1,PCT levels in the study group were positively correlated with CPIS(P<0.05).The ROC curve analysis results showed that serum PSGL-1,ANXA1,PCT levels alone and in combination had higher accuracy in diagnosing acute attack complicated with pulmonary infection.The sensitivity,specificity and accuracy of infection were the highest(P<0.05).Conclusion The levels of serum PSGL-1,ANXA1 and PCT in patients with acute COPD are relatively high and related to the occurrence and severity of lung infections.The combined detection of serum PSGL-1,ANXA1 and PCT levels can be used for the diagnosis of acute exacerbation of COPD complicated by pulmonary infection.
作者
闫秀文
赵艺璞
李亚军
时畅
YAN Xiuwen;ZHAO Yipu;LI Yajun;SHI Chang(Department of respiratory and critical care medicine,Henan Provincial People's Hospital,Henan Key Laboratory of nursing medicine,people's Hospital of Zhengzhou University,Zhengzhou,Henan,China,450003)
出处
《分子诊断与治疗杂志》
2022年第2期274-277,281,共5页
Journal of Molecular Diagnostics and Therapy
基金
2018年度河南省医学科技攻关计划项目(2018093213)。
关键词
P-选择素糖蛋白配体1
膜联蛋白A1
降钙素原
慢性阻塞性肺疾病
肺部感染
P-selectin glycoprotein ligand 1
Annexin A1
Procalcitonin
Chronic obstructive pulmonary disease
Acute exacerbation
Pulmonary infection
