摘要
鞣花单宁是一类中药有效成分。尿石素类化合物是鞣花单宁体内代谢产物及效应成分,具有抗炎、抗氧化应激、抗凋亡等生物活性。尿石素可通过血脑屏障发挥神经保护活性作用,是干预神经退行性疾病的潜在活性小分子。神经退行性疾病是一类由神经元结构或功能逐渐丧失而引发的不可逆性疾病。近年来其发病率不断上升且严重威胁着患者的健康和生活质量,但有效药物始终匮乏。该文综述了尿石素对常见的神经退行性疾病如阿尔茨海默病、帕金森病等的神经保护作用机制的研究进展,为其进一步的研究和应用提供参考。
Ellagitannins are a kind of bioactive components of traditional Chinese medicine,and urolithins are their metabolites and effective components in vivo with anti-inflammation,anti-oxidative stress,anti-apoptotic and other biological activities. Urolithins can pass through the blood-brain barrier and exert neuroprotective activity,and are potent in the intervention of neurodegenerative diseases as small molecules. Neurodegenerative diseases are irreversible diseases triggered by the progressive loss of the structure or function of neurons. In the recent years,the incidence is increasing and seriously threatens the health and quality of life of patients,but effective drugs are still scarce. This review summarizes the research progress of the neuroprotective mechanism of urolithins in the pathogenesis of common neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, and provides reference for further research and application of urolithins.
作者
张诗莹
杨亚玲
黎慧琳
朴秀虹
翟国栋
葛跃伟
ZHANG Shiying;YANG Yaling;LI Huilin;PIAO Xiuhong;ZHAI Guodong;GE Yuewei(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006 Guangdong,China;School of Life Sciences and Biopharmaceutics,Guangdong Pharmaceutical University,Guangzhou 510006,Guangdong,China;Department of Gastroenterology,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120 Guangdong,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2022年第2期273-280,共8页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金项目(82074117,81872988)
广东省基础与应用基础研究基金(2020A1515010472)
广东省医学科研基金项目(B2019032)。
关键词
尿石素
鞣花单宁
神经退行性疾病
阿尔茨海默病
帕金森病
Urolithins
ellagitannins
neurodegenerative diseases
Alzheimer’s disease
Parkinson’s diseases
