摘要
目的:分析直线加速器立体定向放射治疗在中晚期食管癌患者中的效果。方法:选取本院2018年7月~2020年9月接收的72例中晚期食管癌患者作为研究对象,采用随机数字表法分为两组,对照组(36例):常规化疗;观察组(36例):常规化疗+直线加速器立体定向放射治疗。观察两组治疗疗效、肿瘤标志物水平(鳞状上皮细胞癌抗原(SCC-Ag)与角蛋白19片段抗原21-1(CYFRA21-1))、毒副反应(骨髓抑制、恶心、呕吐、放射性肺炎、放射性食管炎)情况。结果:观察组总有效率(97.22%)高于对照组(77.78%),差异具有统计学意义(P<0.05);放疗前两组肿瘤标志物水平对比差异不显著,不具有统计学意义(P>0.05),放疗后观察组低于对照组,差异具有统计学意义(P<0.05);观察组毒副反应发生率(19.44%)略高于对照组(16.67%),但差异不显著,不具有统计学意义(P>0.05)。结论:中晚期食管癌患者应用直线加速器立体定向放射治疗能在保证安全性的同时,降低肿瘤标志物水平,显著提升治疗效果。
Objective:To analyze the effect of linear accelerator stereotactic radiotherapy in patients with advanced esophageal cancer.Methods:The 72 patients with advanced esophageal cancer received in our hospital from July 2018 to September 2020 were selected as the research objects,and they were divided into two groups using a random number table method.The control group(36 cases):conventional chemotherapy;the study group(36 cases):conventional chemotherapy+linear accelerator stereotactic radiotherapy.The therapeutic efficacy,tumor marker levels[squamous cell carcinoma antigen(SCC-Ag)and keratin 19 fragment antigen 21-1(CYFRA21-1)],toxic and side effects(myelosuppression,nausea,vomiting,radioactivity)were observed in the two groups.pneumonia,radiation esophagitis).Results:The total effective rate of the study group(97.22%)was higher than that of the control group(77.78%),and the difference was significant and statistically significant(P<0.05);the difference in the levels of tumor markers between the two groups before radiotherapy was not significant and not statistically significant(P>0.05),the study group was lower than the control group after radiotherapy,the difference was significant and statistically significant(P<0.05);the incidence of side effects in the study group(19.44%)was slightly higher(16.67%),but the difference was not significant,Not statistically significant(P>0.05).Conclusion:Linear accelerator stereotactic radiotherapy for patients with advanced esophageal cancer can not only ensure safety,but also reduce the level of tumor markers and significantly improve the therapeutic effect.
作者
贾国强
田光亮
JIA Guo-qiang;TIAN Guang-liang(Radiotherapy Center,Liaocheng Infectious Diseases Hospital,Shandong Liaocheng 252000)
出处
《中国医疗器械信息》
2022年第1期64-66,共3页
China Medical Device Information
关键词
食管癌
放射治疗
化疗
毒副反应
esophageal cancer
radiotherapy
chemotherapy
toxicity
