摘要
目的 探讨非吸烟女性中 ,被动吸烟与肺癌的关系。方法 通过计算机检索CBM、Medline、中国期刊网、英国国家医学图书馆等 ,并结合文献追溯的方法 ,收集国内外于 1990～ 2 0 0 2年间公开发表的关于非吸烟女性被动吸烟与肺癌的研究文献 ,采用随机效应模型 ,对各研究结果进行Meta分析 ,计算其合并比值比。结果 纳入合并分析的文章共有 14篇 ,合并结果表明 :被动吸烟年限与肺癌的关系无显著意义 ;不同年龄段的被动吸烟与肺癌发病的关系均不显著 (P >0 .0 5 ) ,未成年期和成年期 (婚后 )被动吸烟与肺癌合并OR值分别为 0 .814 1(95 %CI :0 .60 68～ 1.0 92 2 )和 0 .9988(95 %CI :0 .82 0 1～ 1.2 164 ) ;而成年期暴露于丈夫 (配偶 )的合并OR 1.2 784(95 %CI 1.0 3 2 0～ 1.5 83 8) ,关联具有显著意义 ,成年期暴露于工作场所的环境烟草烟雾与肺癌发生的 OR 为 1.0 2 44 (95 % CI:0 .83 2 5～ 1.2 60 6) ,但关联无显著意义。结论 在非吸烟女性中 ,被动吸烟与肺癌的关系仍不明确 ,需要进一步研究和探讨。
To explore the relationship between passive smoking and lung cancer among non-smoking women. By searching CBM, Medline, CNKI and the British National Medical Library combined with a retrospective study, we collected both domestic and overseas published documents between 1990 and 2002 on passive smoking and lung cancer among non-smoking women. Random effect models were applied to conduct Meta analysis on the case control study results, and the combined Odds Ratio (OR) was calculated as well. 14 documents were included into the combined analysis, which indicated that there was no obvious significance between the duration of passive smoking and lung cancer; the correlations between passive smoking and lung cancer attack among different age groups all yielded no prominences (P>0.05); the combined OR for passive smoking and lung cancer during childhood and adulthood (post marriage) were 0.814 1(95% CI: 0.606 8～1.092 2) and 0.998 8 (95% CI: 0.820 1～1.216 4); whereas the combined OR of adults ever exposed to their husbands' (spouses') smoking was 1.278 4 (95% CI: 1.032 0～1.583 8 ) possessing great significance; no significant relationship was found between exposure to environmental tobacco smoke at the workspace among adults and lung cancer occurrence, the OR value of which was 1.024 4 (95% CI: 0.832 5～1.260 6). [Conclusion] Among non-smoking women, the relationship between passive smoking and lung cancer is still unclear, requiring further study and exploration.
出处
《职业与健康》
CAS
2005年第2期168-171,共4页
Occupation and Health
关键词
肺癌
被动吸烟
META分析
Lung cancer, Passive smoking, Meta analysis
