摘要
目的:观察大黄蛭丹汤对高血压脑出血(HICH)微创术后患者疗效及对神经功能恢复和炎症因子水平的影响。方法:选择2018年2月~2020年8月于本院接受HICH微创术的患者124例作为研究对象,随机分为观察组及对照组,每组62例。对照组采用常规方式治疗,观察组在此基础上加用大黄蛭丹汤治疗,比较两组治疗效果,利用美国国立卫生研究院卒中量表(NIHSS)对两组治疗前后神经功能进行比较,利用格拉斯哥昏迷指数(GCS)对两组治疗前后意识情况进行比较,比较两组治疗前后血肿体积;比较两组治疗前后中医症状评分、炎症因子C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)水平及神经功能相关指标Tau蛋白(tau)水平、视锥蛋白样蛋白(VILIP-1)水平。结果:观察组治疗后总有效率为87.10%,相比对照组的72.58%明显升高(P<0.05);观察组治疗后较对照组NIHSS评分、血肿体积明显降低,GCS评分明显升高(P<0.05);观察组治疗后较对照组偏身不利、肢体麻木、口歪眼斜、言语謇涩评分明显降低(P<0.05);观察组治疗后相比对照组CRP、IL-6、TNF-α、Tau、VILIP-1水平明显降低,(P<0.05)。结论:大黄蛭丹汤对HICH微创术后患者的治疗效果良好,可明显改善患者神经功能,缓解炎症反应,具有良好的临床应用价值。
Objective: To explore the curative effect of Dahuang Zhidan Decoction and its influences on recovery of nerve function and levels of inflammatory factors for patients with hypertensive intracerebral hemorrhage(HICH) after minimally invasive surgery.Methods: A total of 124 HICH patients undergoing minimally invasive surgery in the hospital from February 2018 to August 2020 were enrolled as the research objects.They were randomly divided into an observation group and a controlled group, 62 cases in each group.The controlled group was treated with routine methods, while the observation group was additionally treated with Dahuang Zhidan Decoction.The curative treatment was compared between the two groups.The nerve function before and after treatment was compared between the two groups by National Institutes of Health Stroke Scale(NIHSS).The consciousness status before and after treatment was compared between the two groups by Glasgow Coma Scale(GCS).The hematoma volume, scores of TCM symptoms, levels of inflammatory factors [C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)] and nerve function-related indexes [microtubule-associated protein(tau),visinin-like protein-1(VILIP-1)] before and after treatment were compared between the two groups.Results: After treatment, the total response rate of the observation group was significantly higher than that of the controlled group(87.10% vs 72.58%)(P<0.05).After treatment, NIHSS score and hematoma volume in the observation group were significantly lower than those in the controlled group, while GCS score was significantly higher than that in the controlled group(P<0.05).After treatment, scores of body inconvenience, limbs numbness, facial distortion and dysphasia in the observation group were significantly lower than those in the controlled group(P<0.05),and levels of CRP,IL-6,TNF-α,Tau and VILIP-1 were significantly lower than those in the controlled group(P<0.05).Conclusion: Curative effect of Dahuang Zhidan Decoction is good to HICH patients after minimally invasive surgery.It can significantly improve nerve function, and relieve inflammation response, with good clinical application value.
作者
李娇健
董岩
郎朗
刘海兵
曾光
LI Jiaojian;DONG Yan;LANG Lang(Department of Neurology,Fuxin Mining General Hospital of Liaoning Health Industry Group,Fuxin Liaoning 123000,China)
出处
《四川中医》
2021年第12期151-154,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
辽宁省科学技术计划项目(编号:201602208)。
关键词
高血压脑出血
微创术
大黄蛭丹汤
神经功能
炎症因子
Hypertensive intracerebral hemorrhage
Minimally invasive surgery
Dahuang Zhidan Decoction
Nerve function
Inflammatory factor
