摘要
目的探讨持续气道正压通气对阻塞性睡眠呼吸暂停综合征患者氧化应激反应及睡眠质量的影响。方法将97例阻塞性睡眠呼吸暂停综合征患者按随机数字表法分为对照组(49例)及观察组(48例)。两组接受常规治疗,观察组在此基础上联合持续气道正压通气辅助治疗,观察1个月。比较治疗前后两组多导睡眠图数据(氧饱和度下降指数、呼吸暂停低通气指数、血氧饱和度、快速眼动、觉醒指数、最低血氧饱和度)、痰液氧化应激标记物(肿瘤坏死因子、白细胞介素-6、硝基酪氨酸、8-异前列腺素)及匹茨堡睡眠质量指数量表评分。记录两组不良事件发生率。结果治疗1个月两组氧饱和度下降指数、呼吸暂停低通气指数、觉醒指数均较治疗前显著降低(P<0.01),观察组显著低于对照组(P<0.01),两组血氧饱和度、快速眼动、最低血氧饱和度较治疗前显著升高(P<0.01),观察组显著高于对照组(P<0.01)。治疗1个月两组肿瘤坏死因子、白细胞介素-6、硝基酪氨酸、8-异前列腺素水平均较治疗前显著降低(P<0.01),观察组显著低于对照组(P<0.01)。治疗1个月两组匹茨堡睡眠质量指数量表评分较治疗前显著降低(P<0.01),两组间比较差异无统计学意义(P>0.05)。两组不良事件发生率比较差异无统计学意义(P>0.05)。结论持续气道正压通气能明显改善阻塞性睡眠呼吸暂停综合征患者的夜间睡眠呼吸状况,减轻上呼吸道氧化应激反应及炎症反应,提高睡眠质量,安全性高。
Objective To investigate the effect of continuous positive airway pressure(CPAP)on oxidative stress response and sleep quality in patients with obstructive sleep apnea syndrome(OSAS).Methods A total of 97 OSAS patients were divided into a control group(49 cases)and an observation group(48 cases)according to random number table method.All patients received conventional treatment,and the observation group was added with CPAP adjuvant therapy for 1 month.Polysomnography data[oxygen desaturation index(ODI),apnea/hypopnea index(AHI),oxygen saturation(SaO_(2)),rapid eye moving(REM),arousal index,the minimum SaO_(2)],sputum oxidative stress markers[tumor necrosis factor-α(TNF-α),interleukin 6(IL-6),nitrotyrosine(NT),8-iso prostaglandin(8-iso-PG)]and Pittsburgh sleep quality index(PSQI)scores were compared between the two groups before and after treatment.The incidence of adverse events in both groups was recorded.Results One month after treatment,ODI,AHI and arousal index in the two groups were significantly lower than those before treatment(P<0.01),and those in the observation group were significantly lower than those in the control group(P<0.01).SaO_(2),REM and the minimum SaO_(2) in the two groups were significantly higher than those before treatment(P<0.01),and those in the observation group were significantly higher than those in the control group(P<0.01).One month after treatment,the levels of TNF-α,IL-6,NT and 8-iso-PG in both groups were significantly lower than those before treatment(P<0.01),and those in the observation group were significantly lower than those in the control group(P<0.01).One month after treatment,the PSQI scores of the two groups were significantly lower than those before treatment(P<0.01),and there was no significant difference between the two groups(P>0.05).There was no significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusions CPAP can significantly improve the nighttime sleep breathing status of patients with OSAS,reduce upper respiratory tract oxidative stress and inflammation response,improve sleep quality,and have high safety.
作者
陈皓
张珂
李红娟
Chen Hao;Zhang Ke;Li Hongjuan(The Sixth People's Hospital of Anyang,Anyang 455000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2021年第6期117-120,128,共5页
Journal of Clinical Psychosomatic Diseases
基金
安阳市科技发展计划项目(编号2016076533)。
