摘要
目的了解安徽省阜阳市HIV/AIDS患者弓形虫的感染情况,以及弓形虫合并感染对患者CD_(4)^(+)T淋巴细胞计数的影响,为HIV/AIDS患者弓形虫病防控提供参考依据。方法以安徽省阜阳市2020年1月至2021年3月未经治疗新报告的HIV/AIDS患者为调查对象,用酶联免疫吸附试验(ELISA)检测其血清弓形虫IgG抗体,同时检测CD_(4)^(+)T淋巴细胞水平。结果共调查HIV/AIDS患者449例,其中,男性348例,女性75例,36例性别不详;年龄以20~60岁为主。检测出弓形虫IgG抗体阳性5例,阳性率为1.11%。弓形虫IgG抗体阴性的HIV/AIDS患者CD_(4)^(+)T淋巴细胞计数最低为1个/μL,最高为1616个/μL,中位数(四分位间距)为287(170,439)个/μL;弓形虫IgG抗体阳性的HIV/AIDS患者CD_(4)^(+)T淋巴细胞计数最低为43个/μL,最高为325个/μL,中位数(四分位间距)为139(86,237)个/μL,两者间差异无统计学意义(Z=-1.749,P>0.05)。结论安徽省阜阳市HIV/AIDS患者弓形虫感染率较低,CD_(4)^(+)T淋巴细胞水平与弓形虫感染之间的关系有待进一步研究。
Objective To understand the status of Toxoplasma gondii(T.gondii)infection in patients infected with HIV/AIDS in Fuyang City of Anhui Province,and investigate the effect of co-infection on the count of CD_(4)^(+)T lymphocytes for evidence in prevention and control of T.gondii infection in patients infected with HIV/AIDS.Methods The newly reported patients infected with HIV/AIDS without medication were included from January 2020 to March 2021 in Fuyang City.Enzyme-linked immunosorbent assay(ELISA)was performed to measure the serum IgG antibody against T.gondii,and the levels of CD_(4)^(+)T lymphocytes in all subjects.Results Totally,449 HIV/AIDS infected patients(348 males,75 females)underwent the survey.Thirty-six patients were unknown genders,and the patients aged from 20 to 60 years old.IgG antibody positive for T.gondii was detected in 5 patients(1.11%).CD_(4)^(+)T lymphocyte count was from the lowest 1 cell/μL to up to 1616 cells/μL in patients with negative IgG antibody against T.gondii.The median(interquartile range)was 287(170,439)cells/μL.CD_(4)^(+)T lymphocyte count ranged minimally from 43 cells/μL to maximally 325 cells/μL in HIV/AIDS infected patients with IgG antibody positive for T.gondii,with median(interquartile range)of 139(86,237)cells/μL.The difference was insignificant in patients with negative or positive IgG T.gondii antibody(Z=-1.749,P>0.05).Conclusion T.gondii prevalence seems lower in HIV/AIDS infected patients in Fuyang City,and the relationship between CD_(4)^(+)T lymphocyte count and T.gondii infection needs further investigating in such victims.
作者
张远
杜文燕
吴建军
蔡亦红
ZHANG Yuan;DU Wen-yan;WU Jian-jun;CAI Yi-hong(Department of Health Inspection and Quarantine,School of Public Health,Anhui Medical University,Hefei 230032,Anhui Province,China;Anhui Provincial Laboratory of Microbiology and Parasitology,Anhui Medical University;Anhui Provincial Laboratory of Zoonoses of High Institutions,Anhui Medical University;Anhui Provincial Center for Disease Control and Prevention)
出处
《热带病与寄生虫学》
CAS
2021年第6期319-321,共3页
Journal of Tropical Diseases and Parasitology
基金
国家自然科学基金项目(81572801)。
