摘要
目的研究分析嘉兴地区无偿献血者不规则抗体分布特征。方法采用DIAGAST QWALYS 3全自动血型分析仪对2018年11月~2020年11月期间无偿献血者的血液样本进行ABO和RhD血型检测,循常规血型血清学不规则抗体筛查方案,对O细胞有反应的样本,送检参比实验室鉴定其抗体特异性,统计分析不规则抗体特异性及分布特征。结果从90 854例无偿献血者血液样本中共检出不规则抗体样本79例,阳性率0.087%,其中男性样本35例、女性样本44例,女性样本阳性率高于男性样本(χ^(2)=7.503,P<0.05)。年龄组:18~31岁样本29例,32~45岁样本33例,>45岁样本17例(χ^(2)=83.630,P<0.05)。RhD阳性样本的不规则抗体数为73例,RhD阴性样本的不规则抗体数为6例(χ^(2)=84.270,P<0.05)。79例不规则抗体阳性献血者样本中,献血一次阳性的有40例,多次(≥2次)献血为阳性的有39例(χ^(2)=1.484,P>0.05)。结论无偿献血者群体中女性、RhD阴性和年龄>45岁献血者不规则抗体检出率较高,而献血次数与检出率无关。
Objective To study and analyze the profile of irregular antibodies among voluntary blood donors in Jiaxing area. Methods The ABO and RhD blood groups of all voluntary blood donors from November 2018 to November 2020 were detected by DIAGAST QWALYS 3 automatic blood group analyzer. According to routine serological screening program of irregular antibody, the samples reactive to O blood cell were sent to the reference laboratory for further identification of the antibody specificity, and the specificity and distribution characteristics of irregular antibodies were analyzed statistically. Results A total of 79 samples presenting irregular antibodies were yielded out of 90 854 blood samples, with a positive rate of 0.087%. More female samples(n=44) than male(n=35)(P<0.05). 29 donors aged 18 to 31, 33 aged 32 to 45, and 17 aged over 45 years old(P<0.05). 73 samples were RhD positive and 6 were RhD negative(P< 0.05). 40 only donated once, and 39 donated more than twice(P>0.05). Conclusion Female, RhD negative and more than 45 years old blood donors are more likely to present irregular antibodies, regardless of the number of blood donations.
作者
罗振
倪修文
屠佳燕
吴瑾惠
孙佳怡
李筱园
LUO Zhen;NI Xiuwen;TU Jiayan;WU Jinhui;SUN Jiayi;LI Xiaoyuan(Jiaxing Blood Center,Jiaxing 314000,China)
出处
《中国输血杂志》
CAS
2021年第11期1245-1247,共3页
Chinese Journal of Blood Transfusion
基金
浙江省血液安全研究重点实验室开放课题项目(2020KF003)。
关键词
献血者
不规则抗体
分布特征
blood donors
irregular antibody
distribution characteristics
