摘要
Ⅰ目的探讨硝苯地平控释片联合缬沙坦治疗老年2型糖尿病肾病合并高血压的临床疗效及安全性。方法选取2015年8月—2020年8月在该院治疗的200例老年2型糖尿病肾病合并高血压患者作为研究对象,所有患者均给予二甲双胍调节血糖。随机分为两组,对照组使用硝苯地平控释片治疗,观察组使用硝苯地平控释片联合缬沙坦治疗,对比两组的血压、肾功能、肾血管指标、不良反应。结果观察组治疗后SBP、DBP水平明显低于对照组,差异有统计学意义(P<0.05);观察组治疗后Hcy、CysC、UAER、mALB水平明显低于对照组,差异有统计学意义(P<0.05);观察组治疗后TM、COMP水平明显低于对照组,Ang-Ⅰ、Ang-Ⅱ水平明显高于对照组,差异有统计学意义(P<0.05);观察组胃肠道不适、水肿、头晕等不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论硝苯地平控释片联合缬沙坦治疗老年2型糖尿病肾病合并高血压的临床疗效显著,能有效控制血压,改善肾功能,保护肾血管内皮,抑制病情进展,且用药安全性好,具有积极的临床意义。
Objective To investigate the clinical efficacy and safety of nifedipine controlled-release tablets combined with valsartan in the treatment of elderly type 2 diabetic nephropathy with hypertension.Methods The 200 elderly patients with type 2 diabetic nephropathy and hypertension who were treated in the hospital from August 2015 to August 2020 were selectedas the subjects of the study.All patients were given metformin to regulate blood glucose.Randomly divided into two groups.The control group was treated with nifedipine controlled-release tablets,and the observation group was treated with nifedipine controlled-release tablets combined with valsartan.The blood pressure,renal function,renal vascular indexes,and adverse reactions of the two groups were compared.Results The levels of SBP and DBP in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).The levels of Hcy,CysC,UAER and m ALB in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).After treatment,TM and COMP levels in observation group were significantly lower than those in control group,while Ang-Ⅰ and Ang-Ⅱ levels were significantly higher than those in control group,the difference was statistically significant(P<0.05).The incidence of gastrointestinal discomfort,edema,dizziness and other adverse reactions in observation group was significantly lower than that in control group,the difference was statistically significant(P<0.05).Conclusion The clinical effect of nifedipine controlled-release tablets combined with valsartan in the treatment of elderly type 2 diabetic nephropathy with hypertension is significant.It can effectively control blood pressure,improve renal function,protect renal vascular endothelium,inhibit disease progression,and has good drug safety,which has positive clinical significance.
作者
邓伟国
DENG Weiguo(Department of Internal Medicine,Siming Hospital,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian Province,361003 China)
出处
《糖尿病新世界》
2021年第19期82-84,88,共4页
Diabetes New World Magazine
关键词
老年
2型糖尿病肾病合并高血压
硝苯地平控释片
缬沙坦
临床疗效
安全性
Elderly
Type 2 diabetic nephropathy with hypertension
Nifedipine controlled-release tablets
Valsartan
Clinical efficacy
Safety
